Preparation method of sodium phytate-nanosilver modified medical rubber material

A rubber material and nano-silver technology, applied in the field of preparation of medical rubber materials, can solve the problems of increased risk of morbidity and mortality, multiple microbial infections, and patients with failed surgery, and achieve good biocompatibility, no Effects of cytotoxicity, safe antibacterial properties

Inactive Publication Date: 2020-06-02
TAIYUAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are still some problems in medical-grade interventional latex products, such as a slight foreign body sensation after implantation in the human body, and as time goes on, fibronectin, vitronectin, and fibrinogen in blood and tissues will be adsorbed on the material. On the surface, a layer of protein film is formed. Bacteria can easily adhere to this layer of protein film, and then grow and reproduce, gradually forming a layer of stubborn hydrated polysaccharide bioactive film, which causes infection and promotes some non-pathogenic bacteria. Transform into pathogenic bacteria, cause local inflammation and other lesions, lead to operation failure and bring great pain to patients, and in clinical work, some patients need long-term indwelling catheter, but long-term indwelling catheter will lead to a variety of microorganisms infection, with increased risk of morbidity and mortality

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] (1) Take 6ml of natural rubber latex with a solid content of 60%, sieve it with a 120-mesh sieve to remove solid impurities, put the natural rubber latex in a three-necked flask, and stir evenly at a speed of 300r / min for one hour to deaminate the natural rubber latex in a nitrogen atmosphere. Remove a large amount of ammonia in latex.

[0017] (2) Add the natural rubber latex processed in step (1) into a beaker, then add 24ml of the prepared sodium phytate-nano silver solution, stir for 0.5-1h to obtain a uniformly mixed emulsion, pour the emulsion into a petri dish , and naturally dried to prepare a sodium phytate-nanometer silver modified medical rubber material. Simultaneously, a blank control sample was prepared in the same way without adding sodium phytate-nanometer silver to the treated natural rubber latex.

[0018] According to GB / T21510-2008 "Testing method for antibacterial performance of nano-inorganic materials", the antibacterial performance test was carr...

Embodiment 2

[0020] According to the processing method of embodiment 1, the difference of embodiment 2 is: the volume ratio of natural rubber latex and sodium phytate-nanometer silver is 1: 2.

[0021] Refer to Example 1 for antibacterial properties and cytotoxicity tests.

Embodiment 3

[0023] According to the processing method of embodiment 1, the difference of embodiment 3 is: the volume ratio of natural rubber latex and sodium phytate-nanometer silver is 1: 1.

[0024] Refer to Example 1 for antibacterial properties and cytotoxicity tests.

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PUM

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Abstract

The invention discloses a preparation method of a sodium phytate-nanosilver modified medical rubber material. The preparation method comprises the following steps: carrying out impurity removal and deamination pretreatment on natural latex, blending the natural latex with a sodium phytate-nanosilver solution prepared in advance according to a certain volume ratio, and naturally drying to prepare the sodium phytate-nanosilver modified medical rubber material. The medical natural rubber material prepared by the method has antibacterial property from inside to outside, excellent biocompatibilityand no cytotoxicity, can be safely applied to the fields of medicine and the like, and is simple in preparation process, mild in preparation condition and low in cost.

Description

technical field [0001] The invention relates to a preparation method of a medical rubber material, in particular to a preparation method of a medical rubber material modified with sodium phytate-nanometer silver. Background technique [0002] Natural rubber is generally concentrated natural latex or solid natural rubber collected from Hevea brasiliensis trees through a series of processing techniques. It has excellent comprehensive properties and is widely used in industry, agriculture, national defense, and medical treatment. [0003] At present, there are still some problems in medical-grade interventional latex products, such as a slight foreign body sensation after implantation in the human body, and as time goes by, fibronectin, vitronectin, and fibrinogen in blood and tissues will be adsorbed on the material. On the surface, a layer of protein film is formed. Bacteria can easily adhere to this layer of protein film, and then grow and reproduce, gradually forming a laye...

Claims

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Application Information

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Patent Type & AuthorityApplications(China)
IPC IPC(8): C08L7/00C08K5/521C08K3/08
CPCC08K3/08C08K5/521C08K2003/0806C08K2201/011C08L7/00
Inventor魏丽乔张利赵志飞高向华
OwnerTAIYUAN UNIV OF TECH