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Composition containing grapefruit seed extract, preparation method and application thereof

A technology of composition and extract, which is applied in the field of medicine, can solve problems such as difficulty in exerting antibacterial and antiviral effects, and achieve excellent sterilization and disinfection effects, less residue, and excellent sterilization effects

Inactive Publication Date: 2020-06-12
浙江亲水园生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The grapefruit seed extract in this application mainly exerts reducing properties and antioxidant properties, and only shows good inhibitory activity against Escherichia coli, Staphylococcus aureus, Salmonella, and fungi. The main antibacterial substances come from Aromatic alcohol, the composition of this application is mainly used in the antiseptic application of cosmetics as a preservative composition, and it is difficult to exert a wider antibacterial and antiviral effect

Method used

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  • Composition containing grapefruit seed extract, preparation method and application thereof
  • Composition containing grapefruit seed extract, preparation method and application thereof
  • Composition containing grapefruit seed extract, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of the composition containing pomelo seed extract of the present invention comprises the following steps:

[0032]1) Screen the grapefruit seeds, wash them, and freeze the seeds at -25°C to -80°C for 5 hours after drying in the sun, then crush them to a particle size of less than 5mm, and put the crushed seeds into an extraction tank , add 70% ethanol as extractant, extract under stirring conditions at 25°C, keep the ratio of solid to liquid between 1: (10-60), extract for 120 minutes to obtain a crude extract, filter the crude extract to obtain a filtrate ; Then by reclaiming ethanol, the extract is obtained;

[0033] 2) Adding glycerin to the extract, the glycerol is added according to the ratio of the mass ratio of the extract to glycerol of 1: (1.0-2.5), and then adding water for dilution to obtain a dilution, in the dilution Adding citric acid and sodium citrate to obtain a mixed solution, the mass of the citric acid accounts for 0.1%-5% of ...

Embodiment 2

[0055] The composition of the present invention is prepared according to the preparation method of Example 1, the difference being that the dilution factor in step 2) is 300 times, and a common sprayer is used to sterilize the restaurant kitchen (about 50 square meters in area): the number of sprays 30ml per square meter, the total dosage is 1500ml.

[0056] The detection locations are: food storage room, area around the cutting board, dish preparation table, etc.; measuring instrument: LumitesterPD30; the detection value was 12578RLU at the beginning of June 6, 2019, and it dropped to 3110RLU after 5 minutes of stopping the spray, and 891RLU after 10 minutes of stopping (Below 1000RLU meets the general miscellaneous bacteria standard in the hygiene standard of Japanese food processing and catering industry). After continuous observation for a week, it can be kept below 1000RLU. After September 3, spray 15 ml per square meter before closing every day, and continue to monitor ...

Embodiment 3

[0059] Present embodiment is the embodiment that adopts product of the present invention to carry out household indoor disinfection:

[0060] The composition of the present invention is prepared according to the preparation method of Example 1, the difference is that the dilution factor in step 2) is 300 times, and it is prepared as a common spray for disinfection in the household: use a common sprayer to spray the household indoor (area approx. 120 square meters) for sterilization: the spray quantity is 10 milliliters per square meter, and the total dosage is 1200 milliliters. The detection locations are: kitchen, bathroom, living room, bedroom, storage room, etc.; measuring instrument: Lumitester PD30; the highest detection value was 5167 RLU at the beginning of November 12, 2019, and it dropped to 982 RLU after 5 minutes of stopping the spray, and dropped to 982 RLU after 10 minutes of stopping. To 532RLU (below 1000RLU meets the hygienic standards of Japanese food processi...

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Abstract

The invention belongs to the technical field of medicines and discloses a composition containing a grapefruit seed extract, a preparation method and an application thereof. The preparation method comprises the following steps: 1) screening grapefruit seeds, quickly freezing the grapefruit seeds, crushing the grapefruit seeds to a certain particle size, extracting the grapefruit seeds in a stirringmanner by adopting ethanol as an extracting agent to obtain a crude extract, and filtering the crude extract to obtain a filtrate; recovering ethanol to obtain an extracting solution; and 2) adding glycerinum into the extracting solution obtained in the step 1), readding water for dilution, obtaining a diluent, and adding a citric acid and sodium citrate into the diluent so as to obtain the composition of a mixed solution. The composition has a remarkable inactivation effect on common viruses and enveloped viruses, also has an excellent sterilization effect, is safe, non-toxic and not easy toremain, and can be used for preparing antibacterial and antiviral medicines, food and cosmetic additives, medical flushing fluids or medical sprays, and an application range is widened.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition containing pomelo seed extract, a preparation method and an application thereof. Background technique [0002] Viruses are a type of microorganisms that do not have a cell structure and have life characteristics such as inheritance and replication. Like all living things, viruses have the ability to inherit, mutate, and evolve. They are a very small and simple structure of life. Viruses have Highly parasitic, completely dependent on the energy and metabolic system of the host cell, to obtain the materials and energy needed for life activities, leaving the host cell, it is just a large chemical molecule, stops its activity, can be made into protein crystals, and becomes a non-living body When encountering a host cell, it will show typical characteristics of living organisms by absorbing, entering, replicating, assembling, and releasing progeny viruses. T...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K47/10A61P31/16A61P31/14A61P31/04A61K8/9789A61K8/34A61K8/365A61Q17/00A61Q19/00A61L2/22A61L9/14A23L29/00A23L3/3472A23L3/3463A01N65/36A01N37/36A01P1/00A61K31/194A61L101/56A61L101/34A61L101/36
CPCA01N37/36A01N65/00A01N65/36A23L3/3463A23L3/3472A23V2002/00A61K8/345A61K8/365A61K31/194A61K36/752A61K47/10A61K2236/33A61K2800/592A61L2/22A61L9/14A61L2209/21A61Q17/005A61Q19/00A23L29/00A23L29/03A61K8/9789A61P31/04A61P31/14A61P31/16A61K2300/00A23V2250/21162A23V2250/032
Inventor 丁庆
Owner 浙江亲水园生物科技有限公司
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