Preparation method for condensed pill of traditional Chinese medicines

A technology of concentrated pills and traditional Chinese medicine preparations, applied in the field of preparation of concentrated traditional Chinese medicine pills, which can solve the problems of low stability of traditional Chinese medicine concentrated pill powder ratio, affecting product quality and production efficiency, and shortening the production cycle, so as to shorten the dissolution time The effect of shortening the time limit, heating time, and shortening the production cycle

Active Publication Date: 2020-06-16
GUILIN SANJIN PHARMACEUTICALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional Chinese medicine concentrated pill powder produced by this method has low stability in proportion, large difference in pill weight, long dissolution time, and shortened production cycle, which affects product quality and production efficiency.

Method used

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  • Preparation method for condensed pill of traditional Chinese medicines
  • Preparation method for condensed pill of traditional Chinese medicines
  • Preparation method for condensed pill of traditional Chinese medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Liuwei Dihuang Pills (Concentrated Pills)

[0047] 1. Prescription

[0048]

[0049] 2. Preparation method:

[0050] (1) Moutan bark is broken into coarse particles, add 12 times the amount of water and 5% salt, steam distill for 6 hours, collect the distillate, filter the distillate, collect the precipitated crystals, refrigerate the filtrate below 5°C overnight, filter Collect the precipitated crystals, add 5% salt to the filtrate, carry out steam distillation, collect the distillate, refrigerate overnight below 5°C, filter, collect the precipitated crystals, combine all the crystals, dry at low temperature, and control the temperature at 45 ± 5°C.

[0051] (2) The dregs and 1 / 3 of the wine cornus, rehmannia glutinosa, Poria cocos, Alisma alisma, decoct twice with water, add 5 times the amount of water for the first time, 4 times the amount for the second time, 2 hours each time, The decoction was filtered, the filtrates were combined, concentrated under reduced p...

Embodiment 2

[0058] Guipi Pills (Concentrated Pills)

[0059] 1. Prescription

[0060]

[0061] 2. Preparation method

[0062] (1) Take fried Atractylodes macrocephala, Sun-roasted Astragalus membranaceus, Poria cocos, Polygala, fried jujube kernels, longan meat, and jujube (pitted), add water and boil twice, the first time is 3 hours, the second time is 2 hours, and the amount of water added is the second. 5 times the amount once, and 4 times the amount for the second time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to form a clear paste; set aside.

[0063] (2) Take Codonopsis pilosula, Radix Glycyrrhizae, Radix Angelicae Sinensis, and Akiras sinensis and grind them into fine powders, mix them evenly, pass through an 80-mesh sieve, autoclave for sterilization, crush them, pass through an 80-mesh sieve to obtain sterilized fine powders, and set aside.

[0064] (3) Stir and mix the above 91-98% clear paste and 98% fine powder, and adopt continuo...

Embodiment 3

[0068] Shiquan Dabu Pills (Concentrated Pills)

[0069] 1. Prescription

[0070]

[0071] 2. Preparation method:

[0072] (1) Take Codonopsis pilosula, Atractylodes macrocephala, Radix Paeoniae Alba, Astragalus membranaceus, Licorice root, 1 / 2 Poria cocos and 1 / 3 Angelica sinensis, add water and decoct twice, the first time is 3 hours, the second time is 2 hours, add water for the first time 5 times the amount, and 4 times the second time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to clear the paste; set aside.

[0073] (2) Take Rehmannia glutinosa and add water to boil three times, the first time is 3 hours, the second time is 2 hours, the third time is 1 hour, the amount of water added is 5 times the amount for the first time, 3 times the amount for the second time, and 3 times the amount for the third time , combined decoction, filtered, and the filtrate was concentrated under reduced pressure into a clear paste; set aside.

[...

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Abstract

The invention belongs to the field of medicine preparation, and particularly discloses a preparation method for a condensed pill of traditional Chinese medicines. The preparation method comprises thefollowing steps: preparing particles from a part of a medicinal material extract and fine medicinal material powder, carrying out pressing to from a pill mold, adopting the pill mold as a base pill, and rounding the remaining prescription amounts of the medicinal material extract and the fine medicinal material powder and a proper amount of an excipient to form the pill. According to the preparation method disclosed by the invention, effective components can be reserved to the greatest extent; the preparation method well solves problems in proportioning stability of the extract and the medicinal powder; prepared condensed pills are small in pill weight difference, accurate in dosage, shortened in dissolution and dispersion time limit, good in absorption, stable and controllable in qualityand improved in curative effect; a production period is shortened; process is simple; a production environmental is good in sanitation condition; labor intensity is reduced; various quality indexes are obviously improved; and good social and economic benefits are obtained.

Description

technical field [0001] The invention belongs to the field of medicine preparation, and in particular relates to a preparation method of concentrated traditional Chinese medicine pills. Background technique [0002] Concentrated traditional Chinese medicine pills refer to the decoction or extraction and concentration of medicines or part of medicines into extracts, and pills made of suitable auxiliary materials or fine powder of medicines. Concentrated pills are also called ointment pills and extract pills, which have been recorded as early as in "The Back of the Elbow" written by Ge Hong in the Jin Dynasty. Concentrated traditional Chinese medicine pills are a better dosage form among pills at present. It is characterized in that all or part of the medicine is extracted and concentrated, the volume is reduced, it is easy to take and absorb, and it has good efficacy; There are two kinds of preparation methods of concentrated traditional Chinese medicine pills: pan-made pills...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/28A61K47/02A61K47/38A61K47/04A61K47/12
CPCA61K9/28A61K9/2054A61K9/2013A61K9/2009
Inventor 邹节明高江林
Owner GUILIN SANJIN PHARMACEUTICALS CO LTD
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