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Sobering-up liver-protecting extract, sobering-up liver-protecting composition, and preparation method and application of composition

An extract technology for hangover and liver protection, which is applied in the directions of drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of inconvenience in carrying and taking, inconvenient sobering effect, poor flavor acceptability, etc., to achieve hangover and liver protection. Excellent efficacy, overcoming side effects or less obvious effect, unique flavor effect

Active Publication Date: 2020-06-19
GUANGDONG IND TECHN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are various hangover or liver protection products on the market, but there is no brand with absolute influence. As far as the shortcomings of the product itself are concerned, the main reasons are as follows: (1) Product formula design The use of raw materials with poor safety has certain side effects; (2) the efficacy of the product is not strong, and some products have a certain effect of protecting the liver, but the effect of sobering up is not obvious; (3) the products are mostly liquid drinks or solid granules, and the flavor can be Poor acceptance, inconvenient to carry and take

Method used

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  • Sobering-up liver-protecting extract, sobering-up liver-protecting composition, and preparation method and application of composition
  • Sobering-up liver-protecting extract, sobering-up liver-protecting composition, and preparation method and application of composition
  • Sobering-up liver-protecting extract, sobering-up liver-protecting composition, and preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Example 1 Preparation of anti-alcoholic and liver-protecting extract (extract).

[0047] (1) Prepare anti-alcoholic and liver-protecting extract according to Table 1:

[0048] Table 1 (unit is part by mass)

[0049] Formation Extract 1 extract 2 Extract 3 extract 4 Extract 5 Extract 6 Extract 7 Ganoderma lucidum 200 250 300 500 -- 350 350 Wannian Gan 250 150 200 -- 500 -- -- Ume 200 250 150 150 150 150 150 Pueraria -- -- -- -- -- 150 -- licorice -- -- -- -- -- -- 150

[0050]Preparation method: prepare Ganoderma lucidum, Wanniangan, and dark plum three raw materials according to Table 1, and mix them after treatment. Fill the mixture into an ultrasonic-assisted extraction tank. Inject 10 times the water of the material mixture into the ultrasonic-assisted extraction tank for the first time, and extract for 2.0 hours for the first time. After the first extraction, separate the solid...

Embodiment 2

[0059] Example 2 Preparation of anti-alcoholic and liver-protecting composition

[0060] (1) Prepare anti-alcoholic and liver-protecting extract according to Table 2:

[0061] Table 2 (units are parts by mass)

[0062] Formation Composition 1 Composition 2 Composition 3 Comparator 1 Comparator 2 Extract 3 (extract) 180 180 180 180 -- Glutathione 30 50 40 -- 50 Vitamin C 30 20 40 -- 20 Lactoferrin 30 20 10 -- 20

[0063] Preparation method: Prepare the raw materials according to Table 2, and mix them evenly.

[0064] Embodiment effect:

[0065] Human experiment on the detection of alcohol concentration in breath gas after drinking

[0066] Participants: 30 men aged 25 to 40, with an average age of 32.

[0067] Experimental arrangements: The test samples are compositions 1-3 and comparisons 1-2. After each product is tested by the participants, the next experiment is carried out every 3 days. A control group is ...

Embodiment 3

[0069] Example 3 Preparation of Jiejiuhugan Buccal Tablets

[0070] (1) Prepare hangover-protecting liver buccal tablets according to Table 3

[0071] table 3

[0072] group Extract 3 Glutathione Vitamin C Lactoferrin sucrose D-Mannitol L-malic acid Magnesium stearate lozenge 1 180 50 20 20 30 30 1 4 Lozenges 2 180 50 20 20 50 10 3 2 Lozenges 3 180 50 20 20 40 20 2 3

[0073] Preparation method: Add excipients sucrose, L-malic acid, magnesium stearate, and D-mannitol to the extract 3, put it in a high-efficiency wet granulator, dry it until the water content is 3.0%, and carry out granulation in a 30-mesh oscillating granulator. Granules to obtain dry granules. Weigh glutathione, vitamin C, lactoferrin and the dry granules prepared above and place them in a three-dimensional mixer for mixing, and then compress into tablets to obtain hangover liver-protecting buccal tablets with a weight of 1.25 g / tablet. S...

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Abstract

The invention discloses a sobering-up liver-protecting extract, a sobering-up liver-protecting composition, and a preparation method and application of the composition. The extract is prepared from the following components in parts by mass: 200-300 parts of lucid ganoderma, 150-250 parts of Wanniangan and 150-250 parts of dark plum. The composition provided by the invention comprises the anti-hangover liver-protecting extract, glutathione, vitamin C and lactoferrin, has good safety, can be used for both medicines and food, and has nutrients. The extract and composition provided by the invention are natural and safe, have no side effect, have excellent sobering-up and liver-protecting effects, and overcome the defect that products on the market have side effects or have no obvious effect.

Description

technical field [0001] The invention belongs to the field of health food, in particular to a hangover-healing and liver-protecting extract, composition, preparation method and application. Background technique [0002] Wine culture is one of the indispensable activities of our country's traditional culture. From ancient times to the present, Chinese people like to drink very much. Modern medical research reports have found that heavy drinking can damage the digestive system and endocrine system of the human body to varying degrees. Excessive drinking will reduce the ability of the liver to purify the blood, lead to increased toxins in the body, induce liver damage, and even cause liver poisoning, hepatitis, liver disease, etc. hardening. Drinking more than two cups (25ml) of high-concentration alcohol per day will damage the liver. Coupled with the unhealthy lifestyle of modern people, excessive work pressure, drug abuse, etc., the national liver will bear a heavy burden. ...

Claims

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Application Information

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IPC IPC(8): A61K36/736A61K38/06A61K38/40A61K9/20A61K47/26A61K47/10A61K47/12A61P39/02A61P1/16A61K31/375
CPCA61K9/0056A61K9/2013A61K9/2018A61K31/375A61K36/074A61K36/48A61K36/736A61K38/063A61K38/40A61K2236/331A61P1/16A61P39/02A61K2300/00
Inventor 周春晖段迪李静范瑞李平凡龙叶峰冯柏创洪涵熠
Owner GUANGDONG IND TECHN COLLEGE
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