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Two novel naphthoquinone dimers in Li medicine eleutherine americana, preparation method and application thereof

A technology of naphthoquinone dimer and shallot, applied in the field of medicine and biology, can solve problems such as blank, and achieve the effect of simple preparation method

Active Publication Date: 2020-06-19
北京莱万生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the source problem, the foreign research reports on shallots are almost blank, while domestic research on shallots is relatively superficial, and only a small amount of phenolic acids, steroids and a small amount of monoquinones have been obtained from them.

Method used

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  • Two novel naphthoquinone dimers in Li medicine eleutherine americana, preparation method and application thereof
  • Two novel naphthoquinone dimers in Li medicine eleutherine americana, preparation method and application thereof
  • Two novel naphthoquinone dimers in Li medicine eleutherine americana, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] The preparation method of naphthoquinone dimer comprises the following steps:

[0045] S1: Take the dried shallot bulb powder, and use methanol to extract 3 times at room temperature, the ratio of solid to liquid is 1kg:10L, each extraction is 24h, and the methanol extract is concentrated under reduced pressure to obtain the shallot extract;

[0046] S2: Disperse shallot extract in water, and sequentially extract with petroleum ether, chloroform, ethyl acetate and n-butanol to obtain different polar parts;

[0047] S3: Take the ethyl acetate part, load the sample by dry method, pack the column by wet method, and perform silica gel column chromatography (14×100cm, 100-200 mesh), eluting with petroleum ether-ethyl acetate to ethyl acetate-methanol reagent, gradient elution, to obtain different elution sites; the elution gradient is: petroleum ether-ethyl acetate volume ratio 10:1, 5:1, 2:1, 1:1, 0:1, ethyl acetate-methanol Volume ratio 100:1, 80:1, 60:1, 40:1, 30:1, 20:1...

Embodiment 2

[0052] The preparation method of naphthoquinone dimer comprises the following steps:

[0053] S1: Take the dried shallot bulb powder, and use methanol to extract 3 times at room temperature, the ratio of solid to liquid is 1kg:8L, each extraction is 24h, and the methanol extract is concentrated under reduced pressure to obtain the shallot extract;

[0054] S2: Disperse shallot extract in water, and sequentially extract with petroleum ether, chloroform, ethyl acetate and n-butanol to obtain different polar parts;

[0055] S3: Take the ethyl acetate part, load the sample by dry method, pack the column by wet method, and perform silica gel column chromatography (14×100cm, 100-200 mesh), eluting with petroleum ether-ethyl acetate to ethyl acetate-methanol reagent, gradient elution, to obtain different elution sites; the elution gradient is: petroleum ether-ethyl acetate volume ratio 10:1, 5:1, 2:1, 1:1, 0:1, ethyl acetate-methanol Volume ratio 100:1, 80:1, 60:1, 40:1, 30:1, 20:1,...

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Abstract

The invention relates to two novel naphthoquinone dimers in Li medicine eleutherine americana, a preparation method and application thereof, wherein the compounds are obtained by separation through amulti-stage extraction process, and the experiment results prove that the two compounds have obvious antibacterial and anti-tumor activity, so that the two compounds have good application prospects inantibacterial and anti-tumor drugs or health products.

Description

technical field [0001] The invention relates to two novel naphthoquinone dimers in Li medicine red onion and its preparation method and application, belonging to the field of medical biotechnology. Background technique [0002] Red onion (Eleutherine americana) is the whole plant or bulb of the Iridaceae (Iridacea) red allium (Eleutherine) plant. According to "Flora of China", there are about 4 species of Iridaceae Red Allium in the world, including E.blulbosa, E.angusta, E.citriodora, and E.latifolia, which are mainly distributed in Southeast Asia and the Americas. Red onion is bitter in taste and cool in nature. It has the functions of clearing away heat and detoxification, diuresis and dehumidification, dispelling blood stasis, reducing swelling, and stopping bleeding. Its bulbs or whole plants can be used as medicine. It is widely used in clinical practice. , Guangxi and other regions planted and cultivated. Due to the problem of sources, the foreign research reports o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/10C07D311/92A61P35/00
CPCA61P35/00C07D311/92C07D493/10
Inventor 陈德力马国需刘洋洋许旭东魏建和
Owner 北京莱万生物技术有限公司
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