A kind of orthopedic wound antibacterial protective film and preparation method thereof
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A protective film and wound technology, applied in the field of biomedical materials, to achieve the effect of reducing antibacterial agents and reducing the cumulative damage of drugs
Active Publication Date: 2020-12-29
ANQING KANGMINGNA PACKAGING
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[0004] In the prior art, there are few endogenous and exogenous infections of the wound, and the structure of the nursing film is designed to improve the antibacterial rate and reduce the harm of antibacterial agents to the human body
Method used
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Embodiment 1
[0036] An antibacterial protective film for orthopedic wounds, including an endogenous antibacterial protective film that is in contact with the wound and has a pH-sensitive slow-release function, and an exogenous antibacterial film that is in contact with the external environment and has the function of blocking and inhibiting exogenous antibacterial agents. Antimicrobial protective film. The preparation method comprises the following steps:
[0037] S1. PH-sensitive chitosan and nano-silver are dissolved in trifluoroethanol, and the pH is adjusted to 8 to obtain a polymer mass fraction of 4% spinning solution A; the quality of the nano-silver is the pH-sensitive 8% of the quality of chitosan;
[0038] Described pH sensitive type chitosan preparation method is as follows:
[0039] S101. Diamino ortho ester monomer and an appropriate amount of triethylamine are added to the reaction vessel, then methacrylic anhydride is dissolved in methylene chloride (the molar ratio of dia...
Embodiment 1 and comparative example 1
[0056] Table 1 embodiment 1 and comparative example 1 to 3 antimicrobial release rate
[0057]
[0058] As can be seen from Table 1, the orthopedic wound antibacterial protective film prepared in Example 1 has a small release rate of antibacterial agent under neutral conditions, and under acidic conditions, the release rate can reach 81.0% after 40 hours, indicating that the orthopedic wound antibacterial The protective film is acid sensitive. When the wound is under acidic conditions, the orthoester bond in the pH-sensitive chitosan fiber membrane is gradually degraded, so that the cross-linked network is untied, and the antibacterial agent wrapped inside is gradually released slowly, realizing the antibacterial function of endogenous infection. Comparative example 1 only includes the pH-sensitive chitosan fiber membrane, and its release rate is not much different from that of Example 1. However, due to the lack of exogenous antibacterial protective film, when used for wou...
Embodiment 2-3
[0060] Compared with Example 1, the orthopedic wound antibacterial protective film provided by Example 2-3 is different in that, in step S1, the quality of the nano-silver is respectively 2% of the quality of the pH-sensitive chitosan and 10%, the others are basically the same as in Embodiment 1, and will not be repeated here.
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Abstract
The invention provides an orthopedic wound antibacterial protective film and a preparation method thereof. The antibacterial protective film comprises an endogenous antibacterial protective film and an exogenous antibacterial protective film, wherein the endogenous antibacterial protective film is mutually bonded and is in contact with a wound, and the exogenous antibacterial protective film is incontact with the external environment. The endogenous antibacterial protective film is a pH-sensitive degradable high-molecular polymer film loaded with an antibacterial agent, and the pH-sensitive degradable high-molecular polymer comprises acid-sensitive chemical bonds. When inflammation is generated in the wound due to endogenous bacterial infection, the pH value of the wound is reduced, so that the acid-sensitive chemical bonds are broken, and the loaded antibacterial agent is slowly released to inhibit the endogenous bacterial infection. The exogenous antibacterial protective film is a chitosan film grafted with graphene and is used for blocking and inhibiting exogenous bacterial infection. The graphene is connected with the chitosan through chemical bonds and thus cannot enter a human body, so that exogenous bacteria can be effectively inhibited. Therefore, only when endogenous infection occurs, the endogenous antibacterial protective film releases the antibacterial agent, so that the antibacterial agent entering the human body is obviously reduced.
Description
technical field [0001] The invention belongs to the technical field of biomedical materials, and relates to an antibacterial protective film for orthopedic wounds and a preparation method thereof. Background technique [0002] The skin is an important barrier and protective layer against the external environment. In daily life, it is inevitable that external factors such as trauma and burns or human diseases and other factors will cause skin defects to form wounds. During wound healing, bacteria invade the injured site and proliferate at a density of 10 5 CFU / mL, can cause inflammation and infection, hinder wound healing. Bacterial infection of the wound generally includes endogenous infection and exogenous infection. Endogenous infection refers to the infection caused by the normal flora of the immunocompromised patient, that is, the patient himself is a carrier of the pathogen. Cause self-wound infection; exogenous infection refers to the wound infection caused by the fo...
Claims
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