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A preparation method of enteric-coated drug packaging material polyacrylic acid resin II

The technology of polyacrylic acid resin and methacrylic acid is applied in the field of preparation of enteric-coated pharmaceutical packaging material polyacrylic acid resin II, which can solve problems such as unfavorable continuous production, adding materials, and a large amount of foam in emulsion, and achieves low irritation, The effect of improving reactivity and high safety

Inactive Publication Date: 2020-12-01
连云港万泰医药辅料技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anionic emulsifiers used in this preparation process include reactive emulsifiers and sodium dodecylsulfonate. The addition of reactive emulsifiers during the reaction will cause the emulsion to produce a lot of foam, which is not conducive to continuous production and adding materials.

Method used

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  • A preparation method of enteric-coated drug packaging material polyacrylic acid resin II

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Effect test

Embodiment 1

[0039] (1) raw material: methacrylic acid 120g; methyl methacrylate 120;

[0040] Initiator: ammonium persulfate 0.5g;

[0041] Emulsifier: sodium dodecyl sulfonate 1.5g; soybean lecithin 8g;

[0042] Catalyst: ethylene glycol titanium 1g;

[0043] Balance: deionized water 750g;

[0044] Add 750g deionized water, 0.5g ammonium persulfate, 1.5g sodium dodecyl sulfonate; 8g soybean lecithin into the reaction kettle, stir for 15 minutes, add 30g methacrylic acid and 30g methyl methacrylate, while stirring While adding 1g of ethylene glycol titanium, after all the catalysts were added, continue to stir for 20 minutes; mix the remaining 90g of methacrylic acid and 90g of methyl methacrylate, and then move it into a dropping funnel and add dropwise at a rate of 1.5ml / min into the reaction kettle, continue to react at room temperature for 1 hour after the dropwise addition, add methanol to break the emulsion, precipitate, filter with suction, and dry in vacuum to obtain polyacryli...

Embodiment 2

[0046] (1) raw material: methacrylic acid 150g; methyl methacrylate 150;

[0047] Initiator: potassium persulfate 1.0g;

[0048] Emulsifier: sodium dodecyl sulfonate 2.5g; soybean lecithin 5g;

[0049] Catalyst: ethylene glycol titanium 1.5g;

[0050] Balance: deionized water 690g;

[0051] 690g of deionized water, 1.0g of potassium persulfate, 2.5g of sodium dodecyl sulfonate; 5g of soybean lecithin were added to the reactor, stirred for 20 minutes, added with 50g of methacrylic acid and 50g of methyl methacrylate, and stirred while stirring While adding 1.5g of ethylene glycol titanium, after all the catalysts were added, continue to stir for 20 minutes; mix the remaining 100g of methacrylic acid and 100g of methyl methacrylate, and then move it into a dropping funnel, dropwise at a rate of 1.5ml / min Add it to the reaction kettle, continue to react at room temperature for 1 hour after the dropwise addition is completed, add methanol to break the emulsion, precipitate, fil...

Embodiment 3

[0053] (1) raw material: methacrylic acid 135g; methyl methacrylate 135;

[0054] Initiator: sodium persulfate 0.8g;

[0055] Emulsifier: sodium dodecyl sulfonate 2g; soybean lecithin 6g;

[0056] Catalyst: ethylene glycol titanium 2.5g;

[0057] Balance: deionized water 720g;

[0058] 720g of deionized water, 0.8g of sodium persulfate, 2g of sodium dodecyl sulfonate; 6g of soybean lecithin were added to the reactor, stirred for 20 minutes, added with 45g of methacrylic acid and 45g of methyl methacrylate, while stirring Add 2.5g of ethylene glycol titanium, and continue stirring for 20 minutes after all the catalysts are added; mix the remaining 90g of methacrylic acid and 90g of methyl methacrylate, and then move it into a dropping funnel, dropwise at a rate of 1.2ml / min into the reaction kettle, continue to react at room temperature for 1 hour after the dropwise addition, add methanol to break the emulsion, precipitate, filter with suction, and dry in vacuum to obtain po...

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Abstract

The invention provides a preparation method of an enteric-coated drug packaging material polyacrylic resin II, wherein the method uses a natural emulsifier and an anionic emulsifier as composite emulsifiers, adopts a normal-temperature semi-continuous emulsion polymerization method under the action of a catalyst, and has the advantages of no monomer accumulation in the preparation process and uniform copolymerization composition of a generated polymer. The polyacrylic resin II product obtained according to the preparation method is stable in index, moderate in acid value, small in fluctuationamplitude and basically constant in viscosity, and all indexes meet the requirements of the national pharmacopoeia standard.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical packaging materials, and in particular relates to a preparation method of an enteric-coated pharmaceutical packaging material polyacrylic acid resin II. Background technique [0002] Polyacrylic resin II is an anionic copolymer obtained by the copolymerization of methacrylic acid and methyl methacrylate at a ratio of 1:1. It is soluble when pH=6.0 or more, insoluble in water and ether, and soluble in polar organic solvents. Swells in acetone. Polyacrylic resin II is insoluble in gastric juice, only soluble in intestinal juice, and is one of the enteric coating materials recorded in the Chinese Pharmacopoeia. [0003] The industrial research on the synthesis process of polyacrylate drug film coating materials first began in the 1930s, and began to be used for tablet coating in 1972. At present, some acrylic resin coating materials produced at home and abroad are produced by bulk polymeriza...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F220/06C08F220/14C08F2/26C08F2/24C08F4/64A61K47/32
CPCA61K47/32C08F2/24C08F2/26C08F4/64C08F220/06C08F220/14
Inventor 张绍国杨文仲启豪
Owner 连云港万泰医药辅料技术有限公司
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