Methods of inhibiting tumor metastasis
A tumor, tumor cell technology, applied in anti-tumor drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc.
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[0104] Correlation Between Thrombolipin A2 Receptor Gain-of-Function and Metastasis
[0105] Data from the Phenome Wide Association Study (PheWAS) show that a single nucleotide polymorphism (SNP) in the gene TBXA2R causing a gain-of-function variant (T399A) in the thrombolipin A2 receptor is strongly associated with increased tumor metastasisN =32; P=0.003) (Table 1). Figure 7 Primary tumor sites showing metastatic dissemination in patients with the gain-of-function variant T399A. In some embodiments, the invention provides a method of inhibiting metastasis of a solid tumor comprising administering to an individual having the T399A variant a thrombolipin A2 receptor antagonist in an amount effective to inhibit metastasis of the solid tumor in the individual. agent.
[0106] Table 1
[0107]
[0108] Ififtroban reduces both macroscopic and microscopic metastases in the metastatic 4T1 mouse model
[0109] Use the following scheme to convert 1×105 4T1-RFP-luciferase cells...
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