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Methods of inhibiting tumor metastasis

A tumor, tumor cell technology, applied in anti-tumor drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc.

Pending Publication Date: 2020-07-17
VANDERBILT UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] Blocking of metastasis may also have additional indirect benefits

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  • Methods of inhibiting tumor metastasis
  • Methods of inhibiting tumor metastasis
  • Methods of inhibiting tumor metastasis

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[0104] Correlation Between Thrombolipin A2 Receptor Gain-of-Function and Metastasis

[0105] Data from the Phenome Wide Association Study (PheWAS) show that a single nucleotide polymorphism (SNP) in the gene TBXA2R causing a gain-of-function variant (T399A) in the thrombolipin A2 receptor is strongly associated with increased tumor metastasisN =32; P=0.003) (Table 1). Figure 7 Primary tumor sites showing metastatic dissemination in patients with the gain-of-function variant T399A. In some embodiments, the invention provides a method of inhibiting metastasis of a solid tumor comprising administering to an individual having the T399A variant a thrombolipin A2 receptor antagonist in an amount effective to inhibit metastasis of the solid tumor in the individual. agent.

[0106] Table 1

[0107]

[0108] Ififtroban reduces both macroscopic and microscopic metastases in the metastatic 4T1 mouse model

[0109] Use the following scheme to convert 1×105 4T1-RFP-luciferase cells...

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Abstract

Thromboxane A2 receptor antagonists, such as ifetroban, inhibit solid tumor metastasis. The formation of surface and microscopic lung metastases are inhibited. Thromboxane A2 receptor antagonists caninhibit the tumor metastasis process without affecting the growth or development of a primary tumor.

Description

[0001] Related applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 592,365, filed November 29, 2017, which is incorporated herein by reference in its entirety. technical field [0003] The present invention provides methods of inhibiting metastasis of solid tumors using antagonists of the thrombin A2 receptor. Background technique [0004] Cancer remains the leading cause of morbidity and mortality worldwide. For most cancers, cytotoxic chemotherapy has been the standard of care for decades, although new advances in targeted therapy and immunotherapy strategies are changing some cancers' reliance on chemotherapy. Cancer metastasis and recurrence are common concerns throughout all solid cancers initially diagnosed, regardless of treatment progress for some cancers. [0005] Metastatic cancer diagnoses impose significant emotional, social, and economic burdens on individual patients that affect quality of life, in large part because...

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Application Information

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IPC IPC(8): A61K31/427A61K31/4178A61K31/422A61K35/28A61K31/18A61K31/381A61K31/403A61P35/04
CPCA61K45/00A61K31/422A61K31/4178A61K31/427A61K45/06A61P35/04A61K31/18A61K31/381A61K31/403
Inventor J·M·普利R·R·拉维耶里
Owner VANDERBILT UNIV
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