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Delta-like ligand 1 for diagnosing severe infections

一种严重感染、样配体的技术，应用在疾病诊断、动物/人类肽、生物化学设备和方法等方向，能够解决难区分、PCT和CRP有效性脓毒症缺乏、特异性和灵敏度限制等问题

Active Publication Date: 2020-07-17
UNIVERSITY OF HEIDELBERG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] However, the usefulness of PCT and CRP is limited by their lack of specificity and sensitivity for sepsis
In particular, it remains difficult to distinguish sepsis from other non-infectious causes of inflammation

Method used

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  • Delta-like ligand 1 for diagnosing severe infections
  • Delta-like ligand 1 for diagnosing severe infections
  • Delta-like ligand 1 for diagnosing severe infections

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Experimental program
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Embodiment Construction

[0021] Delta-like protein is a single transmembrane protein whose role in the Notch signaling pathway is known, and it is a homologue of the Notch delta ligand described for the first time in Drosophila. Alias ​​for DLL-1 are Delta-like ligand 1, Delta-like protein, H-δ,1, Drosophila Delta homolog 1, Delta-like canonical Notch ligand 1, DL1, Notch ligand Delta-like 1. There are three delta-like genes in mammals, which encode delta-like ligand 1 (DLL1 encodes DLL1), delta-like ligand 3 (DLL3 encodes DLL3), and delta-like ligand 4 (DLL4 encodes DLL4), all of which are Contains a conserved cysteine-rich region known as the DSL (delta, serrated, Lag2) domain, several epidermal growth factor (EGF)-like repeats, and a transmembrane domain. The amino acid sequence of the delta-like ligand 1 protein and the nucleotide sequence encoding the delta-like ligand 1 protein are known. For example, the amino acid sequence of DLL1 is in the document "American Journal of Pathology, Vol.154, No...

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Abstract

The invention refers to a method for in vitro diagnosis of a severe infection. The method comprises determining delta-like ligand 1 protein or a nucleotide sequence coding for delta-like ligand 1 protein in a biological sample, wherein an elevated level of expression of delta-like ligand 1 protein or a nucleotide sequence coding for delta-like ligand 1 protein is indicative of a severe infection.The invention further relates to use of delta-like ligand 1 protein as a biomarker for in vitro diagnosis of a severe infection such as sepsis.

Description

technical field [0001] The present invention relates to the application of δ-like ligand 1 as a biomarker in the diagnosis of severe infection, and to a method for rapidly diagnosing severe infection (such as sepsis) in vitro by controlling the level of δ-like ligand 1 in biological samples. Background technique [0002] A biomarker is a measurable characteristic of an organism that reflects a particular physiological state. In medicine, biomarkers are usually compounds isolated from biological tissues that can be used as indicators of the presence or severity of a particular disease state, or to monitor the effectiveness of interventions used. [0003] Biomarkers are particularly useful in the diagnosis and possibly prognosis of disease, and in monitoring disease progression or response to treatment. Ideal biomarkers should be readily available and measurable, and should be reliable with high sensitivity and specificity for disease. [0004] Severe infections, especially ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/26C07K14/435C12Q1/6876C12Q1/6888C12Q2600/118
Inventor 达格玛·希尔德勃兰特克劳斯·黑格弗洛里安·乌勒马库斯·韦根
Owner UNIVERSITY OF HEIDELBERG