Devices and systems for chromatography column bed support management and related methods

Abstract

Embodiments of the present disclosure may assist in managing, storing, using, and re-using dedicated chromatography column bed supports. For example, devices and systems disclosed herein may include reusable cases for storing dedicated column bed supports when the column bed supports are not in use. Such cases may include one or more dividers and inserts configured to fit column bed supports, andmay be designed and built specifically to ensure efficient, secure storage of column bed supports while minimizing risk of damaging or contaminating them. Methods disclosed herein may include performing a particular chromatography operation in a column, removing the column bed supports from the column, storing the column bed supports in a column bed support storage case, and installing another setof column bed supports in the column for another chromatography operation.

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent No. 62 / 598,091, filed December 13, 2017, the entire contents of which are incorporated herein by reference. technical field [0003] Aspects of the invention relate to devices, systems and methods for managing analytical column bed supports. More specifically, embodiments of the present invention relate to devices, systems, and methods for using, reusing, and storing specialized products for chromatography bed racks. Background technique [0004] Chromatography columns play an important role in the production of biopharmaceutical products. Facilities involved in the production of biopharmaceutical products, or more generally in the performance of chromatographic operations, can be equipped with columns to perform a variety of such operations. Different chromatography operations often involve the use of different materials and methods—for example, different ...

AI Technical Summary

Problems solved by technology

For example, the facility's budget and physical space may not be large enough to accommodate dedicated chromatography columns for each operation in the facility

Alternatively or additionally, the chromatography operations schedule may grow faster than the facility's ability to acquire new chromatography columns

In addition, the chromatographic operations performed by a facility may change over time, for example, the fluctuating need to purify different molecules or manufacture different products, the need to perform multiple different chromatographic operations to purify a single molecule, or the need to test multiple different Types of chromatography operations required

Therefore, it is impractical to have dedicated columns for each of multiple chromatography runs

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