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Repairing and sensitivity-reducing injection and preparation method thereof

A technology of sensitive injection and water for injection, which is applied in the field of repairing and reducing sensitivity injection and its preparation, can solve the problems of adverse consequences of surgery, reduce the sensitivity of the glans, and many adverse reactions, so as to reduce the sensitivity of the penis and repair the chronicity of the penis. Strain, healing effect is good

Inactive Publication Date: 2020-07-31
河南省九转九天生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The theory of penile dorsal neurotomy originates from the "penile hypersensitivity theory", which believes that blocking the conduction of some nerve fibers can reduce the sensitivity of the glans, thereby prolonging the intravaginalejaculatory latency time (IELT) and improving the clinical symptoms of PE , but it has been confirmed by a large number of clinical studies that the total effective rate of dorsal penis neurotomy is only 73.2%, which is not suitable for all PE patients. The treatment method has high limitations, and there are many postoperative adverse reactions. 8.1% of total PE patients undergoing dorsal penile neurotomy (References: Tullii RE, Guillaux CH, Vaccari R, et al. Premature ejaculation-selective neurectomy: a new therapeutic technique-base, indications and results[J].Int J Impot Res , 1994, 6: 109-113. Hetian Erpo, Jiang Wenhui, Ling Zhengbao, et al. Observation on the long-term curative effect of penile dorsal nerve microblocking on primary premature ejaculation [J]. Modern Diagnosis and Treatment, 2015, 26(19 ):4449-4450.)
[0004] Based on the above theoretical basis and the possible adverse consequences of surgery, new research is still needed

Method used

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  • Repairing and sensitivity-reducing injection and preparation method thereof
  • Repairing and sensitivity-reducing injection and preparation method thereof
  • Repairing and sensitivity-reducing injection and preparation method thereof

Examples

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Embodiment 1

[0031] This embodiment provides a method for preparing the repair and desensitization injection, which includes the following steps:

[0032] (1) Divide 950g water for injection with a pH of 5.0 and a microbial content of 5cfu / 100ml into two parts at a weight ratio of 8:2 to obtain 760g of first water for injection and 190g of second water for injection;

[0033] (2) Heat the first water for injection to 30°C, add 8g of sodium hyaluronate and stir, continue heating to 80°C during the period;

[0034] (3) After stirring, after the system is uniformly gel-like, add 10g paeonol sodium sulfonate and 5g methylene blue, stir at 60r / min until completely dissolved, and then add the second water for injection for Constant volume, keep the stirring speed constant, after stirring evenly, first filter through 1μm titanium rod, and then filter through 0.45μm filter element, then heat again to 95℃, then cool to 40℃, sterilize and potting into each 3ml (filled with nitrogen in the ampere flask) is...

Embodiment 2

[0036] This embodiment provides a method for preparing the repair and desensitization injection, which includes the following steps:

[0037] (1) Divide 980g water for injection with a pH of 7.0 and a microbial content of 3cfu / 100ml into two parts at a weight ratio of 9:1 to obtain 882g of first water for injection and 98g of second water for injection;

[0038] (2) Heat the first water for injection to 40°C, add 20g of sodium hyaluronate and stir, continue to heat up to 85°C;

[0039] (3) After stirring, after the system is uniformly gel-like, add 30g paeonol sodium sulfonate and 15g methylene blue, stir at 80r / min until completely dissolved, and then add the second water for injection for Constant volume, keep the stirring speed constant, after stirring evenly, first filter through a 1μm titanium rod, then filter through a 0.45μm filter element for a second time, heat again to raise the temperature to 100°C, and then lower the temperature to 50°C, sterilize and potted into each 3m...

Embodiment 3

[0041] This embodiment provides a method for preparing the repair and desensitization injection, which includes the following steps:

[0042] (1) Divide 969g of water for injection with a pH of 6.0 and a microorganism content of 2cfu / 100ml into two parts at a weight ratio of 9:1 to obtain 872.1g of first water for injection and 96.9g of second water for injection;

[0043] (2) Heat the first water for injection to 35°C, add 10g of sodium hyaluronate and stir, continue to heat up to 82°C;

[0044] (3) After stirring, after the system is uniformly gel-like, add 15g paeonol sodium sulfonate and 6g methylene blue, stir at 70r / min until completely dissolved, and then add the second water for injection for Constant volume, keep the stirring speed unchanged, after stirring evenly, first filter through a 1μm titanium rod, then filter through a 0.45μm filter element for a second time, then heat up again to 98°C, then cool to 45°C, sterilize and potted in order. 3ml (filled with nitrogen in t...

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Abstract

The invention relates to repairing and sensitivity-reducing injection and a preparation method thereof. The repairing and sensitivity-reducing injection comprises the following raw materials in partsby weight: 95 to 98 parts of water for injection, 0.8 to 2.0 parts of sodium hyaluronate, 0.5 to 1.5 parts of methylene blue and 1.0 to 3.0 parts of sodium paeonol sulfonate. The repairing and sensitivity-reducing injection mainly reduces and delays the pleasant sensation of the frenulum and urethra, reduces and delays the pleasant sensation of the glans penis at the same time, and can also play agood repairing role on chronic wounds caused by frequent and excessive stretching of the penis. The preparation method is simple and easy to control, so that large-scale production is facilitated.

Description

Technical field [0001] The invention belongs to the field of medicines, and specifically relates to a repair and hyposensitization injection and a preparation method thereof. Background technique [0002] Premature ejaculation (PE) is one of the most important issues in men’s health. According to data, 20-40% of adult men worldwide suffer from PE of varying degrees. Because the disease involves personal privacy, many patients are taboo. The true incidence may be higher. The pathogenesis of PE has not yet been fully elucidated, and its occurrence may be related to psychological factors and sexual organ factors. At present, clinical treatments are mostly oral serotonin reuptake inhibitors, adrenergic alpha receptor antagonists, and type 5 phosphodiesterases. Medicines or Chinese medicines are the main ones, but most of them have obvious side effects, are expensive, and have poor efficacy. [0003] Local nerve block in PE patients is a common treatment method in surgery. Among them,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/728A61K31/5415A61K31/12A61P15/00
CPCA61K9/08A61K9/0019A61K9/0034A61K9/0009A61K31/728A61K31/5415A61K31/12A61P15/00A61K2300/00A61K31/047A61K31/685A61P25/02
Inventor 梅军
Owner 河南省九转九天生物科技有限公司
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