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Large-view-field head-mounted microscope

A head-mounted, microscope technology, applied in the field of optical imaging, can solve the problems of high cost, the inability of multiphoton microscopes to meet the requirements of functional imaging of massive nerve cells, and low resolution, and achieve the effect of easy acquisition.

Pending Publication Date: 2020-07-31
苏州溢博伦光电仪器有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] With the development of neuroscience in recent years, the narrow field of view of traditional multiphoton microscopes cannot meet the requirements for functional imaging of massive nerve cells. Some research groups have successively realized multiphoton microscopes with super large fields of view.
In 2015, American author P.S.Tsai published the article "Ultra-large field-of-view two-photon microscopy", OptExpress.2015 Jun 1; 23(11):13833-13847. It achieved a diameter of 10mm by optimizing lens chromatic aberration Super large field of view, but its design is based on 0.28 numerical aperture objective lens with 4x magnification, the resolution is too low
These ultra-large field of view and high numerical aperture objective lenses also rely on increasing the diameter of the incident beam to bring a large field of view and have the advantage of a large amount of light. However, the above-mentioned large field of view microscopes will cause the objective lens to be very expensive and bulky. The cost very high

Method used

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  • Large-view-field head-mounted microscope
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  • Large-view-field head-mounted microscope

Examples

Experimental program
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Effect test

Embodiment 1

[0041] The embodiment is basically as attached figure 1 and figure 2 Shown: a head-mounted microscope with a large field of view, including a probe and an imaging unit 11 for imaging an object to be detected. The imaging unit 11 in this embodiment includes a computer and an external amplifier.

[0042] combine figure 2 As shown, the probe includes a housing 1, which is a sealed structure made of high molecular polymer material. The casing 1 includes a lens 4, a scanner 5 and an objective lens 2 sequentially along the direction of the optical path, combined with image 3 As shown, the objective lens 2 includes several eyeglasses. In this embodiment, the objective lens 2 includes the first eyeglass 201, the second eyeglass, the third eyeglass 203, the fourth eyeglass 204 and the fifth eyeglass 205 from left to right, and the first eyeglass 201 There is a surface S11 on the opposite image side and a surface S12 on the opposite object side, the second lens has a surface S21 o...

Embodiment 2

[0056] combine Figure 7 and Figure 8 As shown, a head-mounted microscope with a large field of view differs from Embodiment 1 in that: there is a cylindrical lens 8 between the lens 4 and the objective lens 2 along the optical path, and the cylindrical lens 8 is semi-cylindrical, and the cylindrical lens 8 has a plane One side faces the scanner 5 .

[0057] In this embodiment, when the excitation light emitted by the light source 10 passes through the laser input optical fiber 6 and is collimated by the lens 4, it is focused into a linear focus by the cylindrical lens 8 and acts on the dichroic mirror film 16 for reflection and scanning. , and then the scanning light beam is focused by the objective lens 2 on the external experimental sample 7 on the external stage to form a scanning line, and the emitted light (such as single-photon fluorescence or nonlinear optical signal) excited in the external experimental sample 7 is collected by the objective lens 2 , and then throu...

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Abstract

The invention belongs to the technical field of optical imaging, and specially relates to a large-view-field head-mounted microscope. The microscope comprises a probe and an imaging unit for imaging adetected object. The probe comprises a shell, a lens, a scanner and an objective lens are sequentially arranged in the shell in the light path direction. The objective lens comprises a plurality of lenses, a rear focal plane calculated according to the wavelength of excitation light is located outside the objective lens, the scanner is rotationally connected with the shell, and the scanner is electrically connected with the imaging unit. The viewing angle of the microscope can be increased, and the size of the whole microscope can be reduced.

Description

technical field [0001] The application of the present invention belongs to the technical field of optical imaging, and specifically discloses a head-mounted microscope with a large field of view. Background technique [0002] The large field microscope is a new type of microscope with a wide field of view, which is widely used in biological anatomy, electronic industry, mineral research and other fields. In a large-field microscope, the magnification of the microscope mainly depends on the microscope objective lens. The quality of the microscope objective lens directly affects the quality of the microscope image. It is the main component that determines the resolution and imaging clarity of the microscope. The traditional microscopic objective lens is an optical system with a large aperture angle and a small field of view. Since the microscopic objective lens is used to provide extremely high resolution (about 200nm, super-resolution technology is not considered), its high m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/02G02B21/00
CPCG02B21/002G02B21/02
Inventor 不公告发明人
Owner 苏州溢博伦光电仪器有限公司