A system for identifying TCM syndromes of steroid-induced necrosis of the femoral head through molecular markers

A femoral head necrosis and molecular marker technology, applied in the field of clinical detection, can solve problems such as difficulty in preventing the development of necrosis

Active Publication Date: 2022-06-28
陈卫衡 +1
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  • Summary
  • Abstract
  • Description
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Problems solved by technology

[0004] At present, the most effective method for diagnosing femoral head necrosis is MRI examination, and the early diagnosis rate reaches more than 90%. However, it is difficult to prevent the further development of necrosis after diagnosis

Method used

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  • A system for identifying TCM syndromes of steroid-induced necrosis of the femoral head through molecular markers
  • A system for identifying TCM syndromes of steroid-induced necrosis of the femoral head through molecular markers
  • A system for identifying TCM syndromes of steroid-induced necrosis of the femoral head through molecular markers

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Embodiment

[0067] This example is used to illustrate the discovery of biomarkers and the establishment and validation of prediction models of the present disclosure.

[0068] A total of 60 patients diagnosed with SONFH in Wangjing Hospital of Chinese Academy of Chinese Medical Sciences and Zhengzhou Orthopaedic Hospital of Traditional Chinese Medicine from January 2014 to October 2017 (including phlegm and blood stasis syndrome group, meridian blockage syndrome group, liver and kidney deficiency syndrome group) were collected. 20 cases in each group) as the disease group; at the same time, 20 patients without femoral head necrosis who received hormone therapy in the Hospital of Hematology, Chinese Academy of Medical Sciences were collected as the control group. 80 patients were randomly divided into training set (n=40, phlegm and blood stasis blocking collaterals syndrome, meridian obstruction syndrome, liver and kidney deficiency syndrome, control group, 10 cases each) and validation set...

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Abstract

The disclosure relates to a system for identifying TCM syndrome types of steroid-induced necrosis of the femoral head through molecular markers, wherein the molecular markers include CD28, CD4, PLCG1, PRKCA, PTGS2, SOS2, STAT6, TLR4, IFIT1, IRF7, ISG15, MAPK14 and RHOU. The disclosure can be applied to distinguish different TCM syndrome types of steroid-induced femoral head necrosis by detecting the expression of molecular markers, and assist in early diagnosis, providing an effective basis for guiding clinical diagnosis and treatment.

Description

technical field [0001] The present disclosure relates to the technical field of clinical detection, in particular, to a system for identifying TCM syndrome types of hormonal femoral head necrosis through molecular markers. Background technique [0002] Osteonecrosis of the Femoral Head (ONFH) is a common disease in the department of orthopedics. At present, the number of patients in my country has exceeded 10 million, and the number of new patients is 150,000 to 300,000 every year. Osteonecrosis of the femoral head can be divided into traumatic femoral head necrosis and non-traumatic femoral head necrosis (Nontraumatic Osteonecrosis of the Femoral Head, NONFH). Received glucocorticoid therapy, alcoholism and other reasons. [0003] Steroid-induced osteonecrosis of the femoral head (SONFH) is a non-traumatic femoral head necrosis caused by long-term use of hormones, and its incidence has exceeded that of trauma-induced osteonecrosis. [0004] At present, the most effective ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883G16H50/20G16H50/50
CPCC12Q1/6883G16H50/20G16H50/50C12Q2600/158
Inventor 陈卫衡林娜张彦琼王荣田李泰贤
Owner 陈卫衡
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