A kind of monoclonal antibody and application thereof for neutralizing Epstein-Barr virus

A technology of Epstein-Barr virus and antibodies, applied in the fields of antibodies, applications, antiviral agents, etc., can solve problems such as the marketing of human monoclonal antibodies, and achieve the effect of reducing side effects
CN111548411BActive Publication Date: 2022-03-29SUN YAT SEN UNIV CANCER CENT +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SUN YAT SEN UNIV CANCER CENT
Publication Date
2022-03-29

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Abstract

The present invention discloses an antibody against Epstein-Barr virus for the first time, which is composed of a light chain and a heavy chain. The heavy chain variable region of the heavy chain has three complementary regions CDR1, CDR2 and CDR3, and their amino acid sequences are respectively shown in SEQ ID NO .1-3, the light chain variable region of the light chain has 3 complementary regions CDR1', CDR2' and CDR3', the amino acid sequences of which are respectively as SEQ ID NO.4, GAS, SEQ ID NO.5 shown. The antibody can block EBV infection of epithelial cells with an IC50 of 53ng / ml, but has no neutralizing effect on Ebola virus infection, indicating that the antibody has a high ability to specifically neutralize EBV infection of epithelial cells.
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Description

technical field

[0001] The invention relates to the technical field of antibodies, more specifically, to a monoclonal antibody for neutralizing Epstein-Barr virus and its application. Background technique

[0002] Epstein-Barr virus was first successfully cultivated and established from Burkitt lymphoma cells by Epstein and Barr in 1964. EBV belongs to the gamma subtype herpes virus and is the first human cancer-causing virus discovered. EBV infection is very common in the population, it is reported that more than 95% of adults in the world carry EBV. In children and adolescents, EBV infection frequently causes infectious mononucleosis. EBV latent infection is related to the occurrence of various human lymphoid tumors and epithelial tumors, such as Hodgkin's lymphoma, Burkitt's lymphoma and NK / T cell lymphoma, etc. Epithelial tumors include nasopharyngeal carcinoma and about 10% of gastric cancer, etc. . For organ transplant patients and immunosuppressed patients such as...

Claims

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