Application of MSC to regulation and control of gene expression of effector CD8+ T cells

A cell gene and effect technology, applied in animal cells, vertebrate cells, cell dissociation methods, etc., can solve the problems of antiviral or immune regulation therapy in the treatment of SARS-CoV-2, and achieve strong chemotaxis and strong killing effect of ability

Inactive Publication Date: 2020-08-25
HUNAN YUANPIN CELL TECH CO LTD
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Problems solved by technology

Currently, there are currently no effective antiviral or immunomodulatory therapies for the treatment of SARS-CoV-2, although many clinical trials have begun

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  • Application of MSC to regulation and control of gene expression of effector CD8+ T cells
  • Application of MSC to regulation and control of gene expression of effector CD8+ T cells
  • Application of MSC to regulation and control of gene expression of effector CD8+ T cells

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Embodiment Construction

[0026] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the present invention will be further described in detail below in conjunction with the accompanying drawings.

[0027] It should be noted that the original treatment plan mentioned in the present invention refers to the treatment plan adopted in the new coronavirus pneumonia diagnosis and treatment plan issued by the General Office of the National Health Commission and the Office of the State Administration of Traditional Chinese Medicine. MSC+ means the MSC treatment group , MSC- represents the group without MSC treatment.

[0028] Such as figure 1 As shown, in order to study the application of MSCs for regulating the gene expression of effector CD8+ T cells, the present invention provides a specific steps for the application of MSCs for regulating the gene expression of effector CD8+ T cells in patients with viral infections, including:

[0029] S1, pre...

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Abstract

The invention particularly discloses an application of MSC to regulation and control of gene expression of effector CD8+ T cells, in particular to application of MSC to regulation and control of geneexpression of effector CD8+ T cells of viral infection patients, and relates to the technical field of biomedical engineering. The prepared MSC preparation is added into an MSC treatment group to carry out combined treatment on a patient with viral infection, so that the condition of effector CD8+ T cell gene expression of the patient after the patient is healed through the MSC treatment group iseffectively improved; due to the fact that proliferation of effector CD8+ T cells can be promoted through gene expression of the effector CD8+ T cells, a patient treated through the MSC treatment group has higher anti-inflammatory capacity, and meanwhile a higher chemotactic effect is achieved.

Description

technical field [0001] The invention relates to the technical field of biomedical engineering, in particular to an application of MSCs for regulating gene expression of effector CD8+ T cells. Background technique [0002] There are many important molecules on the surface of T cells, which are involved in T cell antigen recognition, activation, proliferation, differentiation, and effector function. Mature T cells only express CD4 or CD8, that is, CD+ T cells or CD8+ T cells. The main functions of CD4 and CD8 are to assist TCR to recognize antigens and participate in the transduction of T cell activation signals. CD8-expressing T cells (CD8+T cells) usually differentiate into cytotoxic T cells (CTL) after activation, which can specifically kill target cells and secrete various cytokines to participate in immunity. It has a killing effect on antigenic substances such as certain viruses and tumor cells, and forms an important line of defense for the body's anti-virus and anti-...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/28A61P31/12A61P31/14C12N5/0775
CPCA61K35/28A61P31/12A61P31/14C12N5/0665C12N2509/00C12N2509/10
Inventor 陈文明徐远忠胡启旭居雅竹王理波
Owner HUNAN YUANPIN CELL TECH CO LTD
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