A kind of ring metal iridium metformin complex and its preparation method and application
A technology of metformin and its complexes, which is applied in the field of cyclometalated iridium metformin complexes and their preparation, can solve problems such as anti-tumor activity not mentioned, achieve excellent hypoxic anti-tumor activity, simple and easy preparation method, and broad development space Effect
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Embodiment 1
[0054] The preparation of embodiment 1 ring metal iridium metformin complex Ir1
[0055] The preparation method of ring metal iridium metformin complex Ir1 comprises the following steps:
[0056]S1. After mixing iridium trichloride hydrate and ligand at a molar ratio of 1:2.2, dissolve it in a mixed solvent of ethylene glycol ether and ultrapure water (volume ratio: 3:1), and stir at 135°C under reflux The coordination reaction was carried out for 24 hours, cooled to room temperature and suction filtered, and the obtained solid product was washed three times with ultrapure water and diethyl ether, and dried in vacuum to obtain an iridium precursor;
[0057] S2. After mixing the iridium precursor (121.4mg, 0.1mmol) obtained in step S1 with metformin (66.2mg, 0.4mmol), dissolve in dichloromethane / methanol mixed solvent (volume ratio is 1.5:1), in N 2 Potassium tert-butoxide (89.8mg, 0.8mmol) was added under protection, and the reaction was carried out at 35°C for 25h. After the...
Embodiment 2
[0063] The preparation of embodiment 2 ring metal iridium metformin complex Ir2
[0064] The preparation method of ring metal iridium metformin complex Ir2 comprises the following steps:
[0065] S1. After mixing iridium trichloride hydrate and ligand at a molar ratio of 1:2.5, dissolve it in a mixed solvent of ethylene glycol ether and ultrapure water (volume ratio: 2:1), and stir at 130°C under reflux Carry out the coordination reaction for 22 hours, cool to room temperature and suction filter, the obtained solid product is washed 3 times with ultrapure water and diethyl ether, and vacuum-dried to obtain the iridium precursor;
[0066] S2. After mixing the iridium precursor (121.4mg, 0.1mmol) obtained in step S1 with metformin (66.2mg, 0.4mmol), dissolve in dichloromethane / methanol mixed solvent (volume ratio is 2:1), in N 2 Potassium tert-butoxide (89.8mg, 0.8mmol) was added under protection, and the reaction was carried out at 40°C for 30h. After the reaction was complete...
Embodiment 3
[0072] The preparation of embodiment 3 ring metal iridium metformin complex Ir3
[0073] The preparation method of ring metal iridium metformin complex Ir3 comprises the following steps:
[0074] S1. After mixing iridium trichloride hydrate and ligand at a molar ratio of 1:3, dissolve it in a mixed solvent of ethylene glycol ether and ultrapure water (volume ratio: 4:1), and stir at 140°C under reflux Carry out the coordination reaction for 26 hours, cool to room temperature and suction filter, the obtained solid product is washed 3 times with ultrapure water and diethyl ether, and vacuum-dried to obtain the iridium precursor;
[0075] S2. After mixing the iridium precursor (121.4mg, 0.1mmol) obtained in step S1 with metformin (66.2mg, 0.4mmol), dissolve in dichloromethane / methanol mixed solvent (volume ratio is 1:1), in N 2 Potassium tert-butoxide (89.8mg, 0.8mmol) was added under protection, and the reaction was carried out at 30°C for 20h. After the reaction was completed,...
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