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Traditional Chinese medicine compound preparation for improving ovarian dysfunction and preparation method thereof

A technology for ovarian function and compound preparations, applied in pharmaceutical formulas, medical preparations containing active ingredients, drug combinations, etc. Curative effect

Pending Publication Date: 2020-08-28
THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In current clinical practice, hormone replacement therapy is often used for the treatment of ovarian hypofunction. Exogenous supplementation of estrogen or progesterone can maintain physiological sex hormone levels, thereby improving endocrine status in the body and promoting follicle development. However, long-term hormone replacement therapy exists. Increased risk of breast cancer, cardiovascular disease
The androgen DHEA, which can be converted into estrogen and androgen in peripheral tissues, has been used in clinical practice to treat ovarian hypofunction, but the use of DHEA is often accompanied by side effects such as acne

Method used

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  • Traditional Chinese medicine compound preparation for improving ovarian dysfunction and preparation method thereof
  • Traditional Chinese medicine compound preparation for improving ovarian dysfunction and preparation method thereof
  • Traditional Chinese medicine compound preparation for improving ovarian dysfunction and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 prepares this Chinese medicine compound preparation

[0029]Get the raw material medicine of following proportioning by weight: Anemarrhena 9g, Phellodendri 9g, Rehmannia 9g, Tortoise shell 9-15g, Lycium barbarum 9g (or Cuscuta 9g), Ligustrum lucidum 9g, Fairy spleen 9g (or psoralen 9g ), 9g of Morinda officinalis, 9g of red peony root, 9g of white peony root, 10g of raw astragalus, 9g of angelica, 9g of peach kernel, 9g of Chuanxiong 9g, and 9g of jujube kernel; Once, 1 hour each time, combine the water decoction, add 65% to 75% ethanol to make the alcohol content reach 60%, recover the ethanol and then concentrate to make a concentrated solution with a drug volume ratio of 1:1, and dry granulate to make granules. Or made into tablets, capsules, dropping pills.

Embodiment 2

[0030] Embodiment 2 prepares this Chinese medicine compound preparation

[0031] Get the raw material medicine of following proportioning by weight: Anemarrhena 15g, Phellodendron 12g, Rehmannia 20g, Tortoise shell 15g, Lycium barbarum 15g (or Cuscuta 15g), Ligustrum lucidum 15g, Fairy spleen 15g (or psoralen 15g), 15g of Morinda officinalis, 15g of red peony, 15g of white peony, 30g of raw astragalus, 15g of angelica, 15g of peach kernel, 15g of Chuanxiong, 12g of jujube kernel; add 10 times the amount of water, soak for 40min, decoct at 90°C for 2 times, 1 hour each time, combine the water decoction, add 65% to 75% ethanol to make the alcohol content reach 60%, recover the ethanol and then concentrate to form a concentrated solution with a drug volume ratio of 1:1, and dry granulate to make granules, or make Formed into tablets, capsules, dripping pills.

Embodiment 3

[0032] Embodiment 3 prepares this Chinese medicine compound preparation

[0033] Get the raw material medicine of following proportioning by weight: Anemarrhena 12g, Phellodendron 10g, Rehmannia 15g, Tortoise shell 12g, Fructus Lycium barbarum 12g (or Semen Cuscuta 12g), Fructus Ligustrum 12g, Fairy Spleen 12g (or Psoralen 12g), 12g of Morinda officinalis, 12g of red peony, 12g of white peony, 20g of raw astragalus, 12g of angelica, 12g of peach kernel, 12g of Chuanxiong, 10g of wild jujube kernel, add 10 times the amount of water, soak for 40min, decoct at 90°C for 2 times, 1 hour each time, combine the water decoction, add 65% to 75% ethanol to make the alcohol content reach 60%, recover the ethanol and then concentrate to form a concentrated solution with a drug volume ratio of 1:1, and dry granulate to make granules, or make Formed into tablets, capsules, dripping pills.

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Abstract

The invention belongs to the technical field of traditional Chinese medicine pharmacy, and specifically relates to a traditional Chinese medicine compound preparation for improving ovarian dysfunctionand a preparation method thereof. The traditional Chinese medicine compound preparation for improving ovarian dysfunction disclosed by the invention integrates a method of tonifying the kidneys to promote Yang, a method of dispersing the liver to regulate Qi and a method of activating the circulation of the blood to dissipate blood stasis, and is granules, tablets, capsules, dripping pills or powders prepared from the following raw materials: common anemarrhena rhizome, amur cork-tree, raw material, tortoise shell, Chinese wolfberry fruits, fructus ligustri lucidum and herb of shorthorned epimedium as active ingredients, as well as pharmaceutical excipients. Clinical trials prove that the traditional Chinese medicine compound preparation is capable of fundamentally ameliorating ovarian micro-environment, improving ovarian functions, promoting ovarian, maintaining normal hormone levels, and being further used for treating and improving gynecological diseases caused by ovarian dysfunction; and moreover, the traditional Chinese medicine compound preparation is accurate in curative effects, high in safety and capable of alleviating adverse effects produced by western medicines when being used for treating ovarian dysfunction.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine pharmacy, and relates to a compound traditional Chinese medicine preparation for treating gynecological diseases, in particular to a compound traditional Chinese medicine preparation for improving ovarian hypofunction and a preparation method thereof. The compound traditional Chinese medicine preparation of the present invention can treat and improve gynecological diseases caused by hypoovarian function . Background technique [0002] According to the literature, ovarian reserve function refers to the quantity and quality of follicles remaining in the ovary, reflecting the reproductive potential of women. The ability of the ovary to produce eggs is weakened, and the quality of follicle cells decreases, resulting in decreased female fertility and lack of sex hormones, which is called low ovarian reserve. Hypofunction of the ovary is manifested by the low response of the ovary ...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P15/00A61P15/08A61P15/06A61P19/10A61P5/00
CPCA61K36/8964A61K36/756A61K36/804A61K36/815A61K36/296A61K36/71A61K36/65A61K36/481A61K36/232A61K36/236A61K36/725A61P15/00A61P15/08A61P15/06A61P19/10A61P5/00A61K2236/331A61K2236/39A61K2236/51A61K2300/00
Inventor 王凌张娜李丽莎邱学敏潘心瑶陈力嘉周璟李楚宇黄锃恕梁颖婷
Owner THE OBSTETRICS & GYNECOLOGY HOSPITAL OF FUDAN UNIV
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