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Application of short-chain peptide composition in prevention or treatment of xerophthalmia

A dry eye syndrome and composition technology, applied in the field of short-chain peptide compositions, can solve problems such as serious illness of patients, and achieve the effects of increasing eye humidity, promoting corneal repair, and improving acute and long-term dry eye syndrome

Active Publication Date: 2020-09-08
PRO SUNFUN BIOTECH RES & DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Western medicine treatment methods for dry eye syndrome mostly use artificial tear drops and artificial tear ointment, most of which are temporarily effective, but many patients are still getting more and more serious

Method used

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  • Application of short-chain peptide composition in prevention or treatment of xerophthalmia
  • Application of short-chain peptide composition in prevention or treatment of xerophthalmia
  • Application of short-chain peptide composition in prevention or treatment of xerophthalmia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1. The short-chain peptide composition promotes eye corneal repair

[0018] In this example, 500 μl of hydrochloric acid (0.12N, pH=2) was used to corrode the cornea of ​​rabbit eyes, resulting in decreased eye humidity. A 14-day dry eye experiment was conducted in rabbits to evaluate the efficacy of AE250 on dry eye protection. The drug is AE250 dripped 4 times a day, 200μl / time only dripped for 7 days, and stopped dripping AE250 on the 8th day; do the eye humidity test of the left / right eye. The result is as figure 1 shown.

[0019] Depend on figure 1 The results showed that after the rabbit eyes stopped dripping AE250 on the 8th day, compared with the injured group, an increase in eye humidity of 40-50% could indeed improve dry eye syndrome. After the rabbit eyes stopped dripping AE250 on the 8th day, compared with the injured group, AE250 could indeed last for 7 days, which significantly improved the rabbit's acute dry eye syndrome. It is confirmed that ...

Embodiment 2

[0023] Example 2. The Short-chain Peptide Composition Improves Acute Dry Eye Syndrome

[0024] Rabbit eyes are the most sensitive among animals, so this example uses rabbits for acute dry eye experiments. Tropicamide is a short-acting ciliary muscle relaxant that can inhibit the physiological activity of the ocular parasympathetic nerve. Tears are controlled by parasympathetic nerves, so inhibition of parasympathetic nerves inhibits tear secretion, which can be used to cause acute dry eye in rabbits. Establishment of dry eye animal test model: using Tropicamide (0.4% solution dissolved in normal saline to antagonize the parasympathetic muscarinic M3 receptor) to give 5 drops of rabbit eyes in 12 hours , 1 hour after the last drop of rabbit eyes, drop the test drug: in the topicamide group, add physiological saline without short-chain peptide; in the topicamide+AE250 group, add dropwise Physiological saline solution of peptide composition. 1 hour after dropping the test medi...

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Abstract

The invention relates to an application of a short-chain peptide composition in prevention or treatment of xerophthalmia. The short-chain peptide composition disclosed by the invention comprises a short-chain peptide consisting of 5-10 amino acids, and has the effects of promoting corneal repair, increasing eye humidity and improving xerophthalmia.

Description

technical field [0001] The invention relates to a short-chain peptide composition for preventing or treating dry eye. More particularly, the present invention relates to a short-chain peptide comprising one or more oligopeptides whose structure is a combination of 5-10 amino acids selected from Serine, Lysine and other amino acids The composition is used for promoting corneal repair, increasing eye moisture and improving dry eye syndrome. Background technique [0002] Dry eye disease (DED), also known as keratoconjunctivitis sicca (KCS), is a state of dry eyes, mainly due to insufficient or uneven tear secretion or excessive tear evaporation. , causing tears to fail to properly moisten the surface of the eyeball. Common symptoms include dry eyes, easy fatigue, foreign body sensation, burning sensation, tight and heavy eyelids, thick secretions, fear of wind, photophobia, and in severe cases, the eyes will be red, swollen, congested, keratinized, and long-term damage It ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/08A61P27/02A61P27/04
CPCA61K38/08A61P27/02A61P27/04
Inventor 侯建维李英中贾铜安戴瑞凡
Owner PRO SUNFUN BIOTECH RES & DEV CO LTD
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