Preparation process of oseltamivir phosphate capsules

A technology for the preparation of oseltamivir phosphate and capsules, which is applied in the directions of capsule delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc. It can prevent the flow of A and B, the effect is excellent, and the treatment is good.

Inactive Publication Date: 2020-09-15
WUHU YANGYAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, for the production and manufacture of oseltamivir phosphate capsules, the manufacturing process is not good, resulting in poor effect of oseltamivir phosphate capsules

Method used

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Examples

Experimental program
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Effect test

Embodiment Construction

[0015] In order to deepen the understanding of the present invention, the present invention will be further described below in conjunction with examples, which are only used to explain the present invention and do not constitute a limitation to the protection scope of the present invention.

[0016] This example provides a preparation process for oseltamivir phosphate capsules, which includes the following steps: Step 1: Screening: Weigh API, pregelatinized starch, povidone (K30) and cross-linked carboxymethyl cellulose Sodium plain, then sieve separately to reach the specified mesh number;

[0017] Step 2: Mixing: first add the raw material API into the wet granulator, then add the rest of the materials, turn on the stirring paddle, and mix;

[0018] Step 3: Add wetting agent: turn on the stirring and cutting knife, and add wetting agent to the material;

[0019] Step 4: Granulation: Turn on the stirring and cutting knife for granulation;

[0020] Step 5: Drying: Add the we...

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Abstract

The invention aims to provide a preparation process of oseltamivir phosphate capsules. Oseltamivir phosphate capsule bulk drugs API, pregelatinized starch, povidone (K30) and croscarmellose sodium aresieved; mixing and wetting are carried out; a hopper mixer is used for mixing; granulating is carried out by adopting a wet granulator; granulating with a granulator after drying is completed; then the granulated mixture is mixed with talcum powder and sodium stearate fumarate to obtain oseltamivir phosphate granules; and filling is carried out by using a capsule machine to obtain the oseltamivirphosphate capsules. The prepared oseltamivir phosphate capsules are excellent in effect, has good efficacy of treating and preventing type A influenza and type B influenza, and is suitable for production.

Description

technical field [0001] The invention relates to the field of preparation of oseltamivir phosphate capsules, in particular to a preparation process of oseltamivir phosphate capsules. Background technique [0002] Oseltamivir Phosphate Capsules, indications are: for the treatment of influenza A and B in adults and children over 1 year old (Oseltamivir Phosphate can effectively treat Influenza A and B, but Influenza B There are not many clinical application data). Patients should use it within 48 hours of the first onset of symptoms, and for the prevention of influenza A and B in adults and adolescents aged 13 and over. At present, for the production and manufacture of oseltamivir phosphate capsules, the manufacturing process is not good, resulting in poor effect of oseltamivir phosphate capsules. Therefore, it is necessary to solve this problem. Contents of the invention [0003] In order to solve the above problems, the present invention provides a preparation process of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/48A61K31/215A61K47/38A61P31/16
CPCA61K9/1652A61K31/215A61P31/16
Inventor 李钦民李钦国
Owner WUHU YANGYAN PHARMA
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