Heptamethine carboxyl indocyanine dye, preparation method and application thereof

A technology of heptamethine carboxyl and indole cyanine, applied in the direction of methine/polymethine dyes, organic dyes, chemical instruments and methods, etc., can solve the problems of large consumption of organic solvents, high price, low purity, etc.
CN111662567APending Publication Date: 2020-09-15NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
Publication Date
2020-09-15

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Abstract

The invention discloses a heptamethine carboxyl indocyanine dye, a preparation method and application thereof, and belongs to the field of polymethine indocyanine dyes and preparation thereof, whereinthe structural formula of the heptamethine carboxyl indocyanine dye is represented by a formula (I), and the dye has near-infrared light absorption and fluorescence development properties, and can beused as a probe auxiliary agent. The preparation method of the dye comprises the following steps: 1) carrying out a heating reaction on raw materials containing a 2,3,3-trimethyl-carboxyl indole derivative and a nucleophilic substituted compound under a vacuum condition to obtain an organic ammonium salt; and 2) carrying out a heating reaction on a solution containing the organic ammonium salt obtained in the step (1) and a cycloalkene derivative under a closed condition. The method has the advantages of short synthesis route, environment-friendly solvent, simple process, avoidance of noble metal catalysis, high yield, high purity and the like, is high in applicability, and can be used for synthesizing products of various structure types.
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Description

technical field

[0001] The application relates to a heptamethine carboxy indole cyanine dye and its preparation method and application, belonging to the field of polymethine indole cyanine dye and its preparation. Background technique

[0002] The indocyanine green in the heptamethine cyanine dye is the only near-infrared dye approved by the US Food and Drug Administration for clinical photothermal therapy, and its derivative new indocyanine green belongs to the heptamethine indocyanine dye kind of. This type of dye has a strong absorption effect in the near-infrared region around 808nm, which can be used as a complement to other medical diagnostic methods (such as MRI, PET, SPECT, ultrasound echo scanning technology, radiography and tomography) Imaging technology, also used as a photosensitizer for photothermal therapy, has important research and application value in life science and biomedical research.

[0003] Heptamethine indole cyanine dyes have multiple modifiable s...

Claims

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