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Biomarkers and their applications for diagnosing cognitive impairment

A cognitive impairment and biomarker technology, applied in the field of biological detection, can solve unclear problems

Active Publication Date: 2020-11-20
BAO FENG BIOTECH (BEIJING) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And these results prove that metabolic disorders may indicate the occurrence of cognitive impairment, but it is not clear which substance can be clearly detected as cognitive impairment

Method used

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  • Biomarkers and their applications for diagnosing cognitive impairment
  • Biomarkers and their applications for diagnosing cognitive impairment
  • Biomarkers and their applications for diagnosing cognitive impairment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 1. Patient Population Standards

[0026] 1. Model building sample group of 80 people (internal population, refers to the sample group used when building the prediction model)

[0027] Control population: male to female ratio is 1:1, age range: over 45 years old, MMSE scale score > 26 points, and Moca scale score > 27 points, MRI nuclear magnetic resonance examination showed no abnormalities.

[0028] Patient population: The male to female ratio is 1:1, the age range is over 45 years old, the MMSE scale score is <26 points, and the Moca scale score is <27 points, and the MRI nuclear magnetic detection part shows abnormalities.

[0029] 2. Model verification sample group of 80 people (external population, refers to the sample used for model verification (not internal population)) The sampling standard is the same as above.

[0030] 2. Experimental instruments and reagents

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PUM

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Abstract

The present invention provides the application of the biomarker SM (d18:1 / 24:1(15Z)) in the preparation of reagents or kits for diagnosing cognitive impairment, which can be detected by detecting the biomarker SM (d18:1 / 24:1( 15Z)) and TG(16:0 / 18:0 / 18:4(6Z,9Z,12Z,15Z)), PC(P-16:0 / 22:4(7Z,10Z,13Z,16Z)) or PC(P‑18:0 / 18:4(6Z,9Z,12Z,15Z)) can be used to judge whether patients have cognitive impairment.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and in particular relates to a biomarker for diagnosing cognitive impairment and its application. Background technique [0002] As we all know, cognitive impairment is a progressive neurodegenerative disease. If cognitive impairment is not detected, concerned and intervened early, it will easily develop into dementia, such as Alzheimer's disease (AD). [0003] The senile plaques of extracellular β-amyloid deposition in the whole brain of AD patients and the death of intracellular hyperphosphorylated tau protein nerve cells are the main causes of Alzheimer's disease, which is a disease that leads to progressive memory impairment, Cognitive deficits, changes in personality, etc. There are more than 5 million people with Alzheimer's disease in the world, and the number of patients with cognitive impairment is even higher. [0004] Studies have shown that there are more than ten millio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86G01N33/92
CPCG01N30/02G01N30/06G01N30/86G01N33/92G01N2030/062G01N2800/2814G01N33/6896G01N2405/02G01N2405/04G01N2405/08G01N33/6848G01N2800/52A61P25/28
Inventor 陈显扬宋王婷韩佳睿薛腾
Owner BAO FENG BIOTECH (BEIJING) CO LTD