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Application of 2-hydroxyesterol or derivative thereof

A technology of hydroxyestradiol and derivatives, which is applied in the field of medicine to achieve low cost and remarkable effect

Pending Publication Date: 2020-10-09
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] It can limit the synthesis of catecholamines by inhibiting the activity of tyrosine hydroxylase, but there is no report on the effect of 2-hydroxyestradiol on CRS

Method used

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  • Application of 2-hydroxyesterol or derivative thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1. Freshmen (0-2 days) SGM3 (NSG Tg CMV-IL3, CSF2, KITLG 1Eav / MloySzJ) mice are irradiated with a sublethal dose (150cGy), immediately injected 1×10 intrahepatic 5 Human umbilical cord blood CD34+ cells were used to prepare nHuSGM3 humanized mice. CD19Car T cells were prepared using nHuSGM3 humanized mouse T cells.

[0037] 2. Adult (6-8 weeks) SGM3 (NSG Tg CMV-IL3, CSF2, KITLG 1Eav / MloySzJ) mice were irradiated with a sublethal dose (200cGy) and immediately injected 1×10 into the tail vein 5 Human umbilical cord blood CD34+ cells to prepare HuSGM3 humanized mice.

[0038] After 3.4 weeks, 2×10 was injected into the tail vein 6 Two CD19Car T cells prepared from nHuSGM3 humanized mice.

[0039] 4. Immediately after the injection of Car T cells, intraperitoneal injection of 2-hydroxyestradiol 10mg / kg or equal volume of PBS daily for 5 consecutive days.

[0040] 5. After injecting Car T cells, weigh the mouse body weight and measure the body temperature of the mouse every day; t...

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PUM

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Abstract

The invention relates to the technical field of medicines, in particular to an application of 2-hydroxyestradiol or a derivative thereof. The research shows that the 2-hydroxyestradiol or the derivative thereof can inhibit the rise of cytokine level caused by CRS, inhibit the rise of body temperature caused by CRS, maintain the weight of an animal receiving adoptive immunotherapy and relieve and / or treat CRS. Compared with the scheme that antibody drugs can only inhibit the activity of one cytokine in the prior art, the technical scheme is lower in cost, can inhibit the activity of various cytokines at the same time, and is remarkable in effect.

Description

Technical field [0001] The present invention relates to the field of medical technology, in particular to the use of 2-hydroxyestradiol or its derivatives. Background technique [0002] In recent years, the T cell therapy technology that uses genetic modification technology to express tumor-specific chimeric antigen receptor (Car) has progressed rapidly. Car T has shown good killing activity, targeting and durability in clinical and clinical trials, providing new and effective solutions for tumor treatment, showing great application potential and development prospects. The American Society of Clinical Oncology will It was named the biggest research breakthrough in 2017. On August 31, 2017, the FDA approved Novartis’ Kymriah for the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia in children and young adults. On October 18, 2017, it approved the listing of Yescarta, the world’s second CAR T therapy. The launch of these products makes Car T cell therapy at...

Claims

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Application Information

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IPC IPC(8): A61K31/565A61K35/17A61P35/00
CPCA61K31/565A61K35/17A61P35/00A61K2300/00
Inventor 万晓春刘茂玄许晨光
Owner SHENZHEN INST OF ADVANCED TECH
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