Application of carboline compounds in preparation of drugs for resisting human tongue squamous cell carcinoma

A tongue squamous cell carcinoma and compound technology, applied in the field of medicine, can solve the problem of high postoperative recurrence and metastasis rate

Inactive Publication Date: 2020-10-16
南京盖斯夫医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, comprehensive sequential treatment methods are used, supplemented by surgery, radiotherapy and chemotherapy. The postop...

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  • Application of carboline compounds in preparation of drugs for resisting human tongue squamous cell carcinoma
  • Application of carboline compounds in preparation of drugs for resisting human tongue squamous cell carcinoma

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Embodiment Construction

[0021] The substantive content of the present invention will be specifically introduced below in conjunction with the embodiments. Due to space reasons, the description of the experimental process cannot be done in great detail. All the parts not described in detail in the experiment are routine operations well known to those skilled in the art.

[0022] 1. Experimental materials

[0023] Human tongue squamous cell carcinoma CAL-27 cells were purchased from ATCC and cultured with RPMI-1640 containing 10% fetal bovine serum at 37°C, 5% CO 2 Routine culture in a cell culture incubator.

[0024] RPMI-1640 medium and fetal bovine serum were purchased from Gibco, USA.

[0025] The chemical structures of carboline compounds A and B to be tested are as follows: figure 1 As shown, the purity is ≥98%.

[0026] 2. Experimental method

[0027] 1. Determination of cell proliferation activity

[0028] Human tongue squamous cell carcinoma CAL-27 cells in the logarithmic growth phase we...

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Abstract

The invention discloses application of carboline compounds in preparation of drugs for resisting human tongue squamous cell carcinoma. According to the application, discovered through researches, on one hand, the carboline compounds A and B can inhibit growth and propagation of a human tongue squamous cell carcinoma cell CAL-27, and on the other hand, activity of migration of the human tongue squamous cell carcinoma cell CAL-27 can be inhibited, so that the carboline compounds A and B can be developed into antitumor drugs for inhibiting growth and/or transferring of the human tongue squamous cell carcinoma.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of a carboline compound in the preparation of anti-squamous cell carcinoma of the human tongue. Background technique [0002] Tongue squamous cell carcinoma is the most common malignant tumor in oral cancer. It is generally highly malignant, grows fast, and has strong infiltration. Early lymph node metastasis often occurs. At present, the comprehensive sequential treatment method with surgery as the mainstay, radiotherapy and chemotherapy as the supplementary treatment has a high rate of postoperative recurrence and metastasis, and the 5-year survival rate after comprehensive treatment is only about 50%. [0003] Chemotherapy is a systemic treatment with wide clinical application. For patients with squamous cell carcinoma of the tongue, the drug of choice is fluorouracil (5-Fu), but clinical resistance to 5-Fu is also common. [0004] Therefore, it is necessary to continuo...

Claims

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Application Information

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IPC IPC(8): A61K31/437A61P35/00A61P35/04
CPCA61K31/437A61P35/00A61P35/04
Inventor 不公告发明人
Owner 南京盖斯夫医药科技有限公司
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