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Biodegradable radioactive particle, particle composition and preparation method thereof

A technology of radioactive particles and radioactivity, which is applied in the directions of radioactive preparations, radioactive physical shapes, and drug combinations in the body, and can solve the problems of high welding technology requirements, irritation, and leakage of local tissues.

Active Publication Date: 2020-10-30
HTA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, since the radioactive particles currently used in clinical brachytherapy are all non-biodegradable products, especially for permanently implanted radioactive particles, after the completion of the treatment process, the radioactive particles will permanently remain in human tissues. Although most of the remaining radioactive particles will be solidified in the calcified lesion tissue after treatment, a small number of radioactive particles may migrate, thereby posing health risks to other tissues of the human body
In addition, the metal casing that stays in the tissue for a long time also has the risk of leakage and irritation to local tissues. Moreover, the metal casing will also shield a certain proportion of the radioactive ray intensity, so that the shielding factor of the casing must be considered when designing the dose of radioactive particles, increasing the cost of radioactive particles
[0004] For the existing method for preparing radioactive particles in a metal shell, the main process is to weld and seal the material adsorbed with radionuclides in the metal shell, which has high requirements for welding technology, high difficulty in realizing automation, low production efficiency, and restrictions on radioactive materials. The operation is easy to cause defects such as radioactive contamination

Method used

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  • Biodegradable radioactive particle, particle composition and preparation method thereof
  • Biodegradable radioactive particle, particle composition and preparation method thereof
  • Biodegradable radioactive particle, particle composition and preparation method thereof

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specific Embodiment 1

[0052] Biodegradable radioactive particles and compositions consist of the following components:

[0053] Shell composition:

[0054] Polycaprolactone 100 parts

[0055] Radioactive Core Composition:

[0056] iodine[ 125 I] sodium chloride 10 parts

[0057] Calcium Alginate Hydrogel 100 parts

specific Embodiment 2

[0059] Biodegradable radioactive particles and compositions consist of the following components:

[0060] Shell composition:

[0061] Polycaprolactone 90 parts

[0062] 5-fluorouracil 10 parts

[0063] Radioactive Core Composition:

[0064]

[0065] Different from the features of the prior art, the biodegradable radioactive particle and its composition provided by the present invention have the following advantages:

[0066] 1. The radioactive particles provided by the present invention are biodegradable, that is, after the radioactive particles are implanted into the lesion tissue and complete all therapeutic functions, their outer shell and inner core will be degraded by various mechanisms such as hydrolysis and enzymolysis to be biodegradable by the human body. Small molecular components that are metabolized or directly excreted from the body will not affect the function of the patient's tissue after treatment.

[0067] 2. The shape and size of the biodegradable radi...

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Abstract

The invention provides a biodegradable radioactive particle, a particle composition and a preparation method thereof. The radioactive particle comprises a radioactive inner core and a shell, wherein the radioactive inner core comprises radionuclide and alginate hydrogel; and the shell is made of polycaprolactone. The radioactive particle has the advantages of complete degradation in vivo, convenience in clinical use, capability of simultaneously realizing radioactive ray treatment and medicine local treatment, high preparation efficiency, capability of realizing continuous large-scale full-automatic production, full-closed preparation process, capability of preparing radioactive particles meeting the clinical requirements of complex lesion conditions, and the like.

Description

technical field [0001] The invention belongs to the technical field of brachytherapy devices, and in particular relates to a biodegradable radioactive particle, a particle composition and a preparation method. Background technique [0002] Radiation therapy has always been a common treatment method for malignant tumors. The use of radioactive particles for interstitial brachytherapy of tumors is a new technology developed in recent decades. Radioactive particles are a small radioactive source, which contains radioactive isotopes in titanium tubes or other biocompatible metal tubes, and the two ends are welded by laser or electron beam technology to form a sealed source, and its size is generally 0.8mm in outer diameter , the length is 4.5mm. Nuclides commonly used in radioactive particles are 192 Ir, 198 Au, 169 Y, 131 Cs, 103 Pd and 125 I etc., especially 103 Pd and 1 25I. Brachytherapy implants radioactive particles directly into the lesion, and continuously irra...

Claims

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Application Information

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IPC IPC(8): A61K51/06A61K51/12A61K45/00A61K49/04A61N5/10A61P29/00A61P35/00A61P37/06A61K101/02A61K103/32A61K103/00
CPCA61K51/06A61K51/1265A61K51/1213A61K45/00A61K49/048A61K49/0404A61K49/0438A61N5/10A61P35/00A61P37/06A61P29/00A61N2005/1085
Inventor 张文辉高惠波李忠勇
Owner HTA CO LTD
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