The invention relates to a preparation method of a nano-microcapsule adopting
chitosan-TPP-KGM as a compound
wall material. The preparation method comprises the following steps: preparing
chitosan solution with the
mass percentage being 0.2-0.5 % (%, w / v), mixing TPP solution with KGM solution, and dropwise adding the mixed liquid of the two substances into the
chitosan solution; carrying out magnetic stirring while dropwise adding is carried out till the mixed liquid is completely dropwise added, carrying out further stirring for 15-60 min at 10-50 DEG C, carrying out centrifugalizing, collecting nano-capsules, and carrying out flushing by adopting double
distilled water, thus obtaining the chitosan-TPP-KGM compound nano-microcapsule, wherein the CPP-Ca<2+> compound is adopted as a modelmedicine for embedding. The
loading rate of the microcapsule for the core material is high, the targeting and slow release effects are very good, and the microcapsule can be widely applied in the aspects including
medicine slow release,
food industry, biological functional materials, and the like.