Pillar[5]arene artificial transmembrane channel having antibacterial activity, and production method and application thereof

A technology of antibacterial activity and transmembrane channel, applied in the field of artificial transmembrane channel of column [5] aromatics and its preparation, can solve the problems of difficult to eliminate hemolytic toxicity, low antibacterial activity, low hemolytic toxicity, etc., and achieve inhibition of bacterial growth , excellent antibacterial properties, the effect of changing permeability
CN108017690AActive Publication Date: 2018-05-11HENAN NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HENAN NORMAL UNIV
Publication Date
2018-05-11

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Abstract

The invention discloses a pillar[5]arene artificial transmembrane channel having an antibacterial activity, and a production method and an application thereof, and belongs to the technical field of compounds having an antibacterial activity. The structural general formula of the pillar[5]arene artificial transmembrane channel having the antibacterial activity is shown in the description. The invention also discloses the production method of the pillar[5]arene artificial transmembrane channel having the antibacterial activity, and an application of the pillar[5]arene artificial transmembrane channel in the preparation of medicines for treating or preventing bacterium induced diseases. The artificial transmembrane channel produced in the invention has an excellent antibacterial performance,so the artificial transmembrane channel can be well applied to the prevention and treatment of bacterium induced animal and plant diseases; and the produced artificial transmembrane channel has very low hemolysis toxicity, so the artificial transmembrane channel can be used as a whole-body ion channel type antibiotic candidate medicine.
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Description

Technical field

[0001] The invention belongs to the synthetic technical field of compounds with antibacterial activity, and specifically relates to a column [5] aromatic hydrocarbon artificial transmembrane channel with antibacterial activity, and a preparation method and application thereof. Background technique

[0002] Pathogenic infectious diseases caused by bacteria, viruses, fungi, etc. pose a serious threat to human and animal health. So far, traditional antibiotics are still the first choice for the treatment of such infectious diseases. However, with the use of antibiotics, people gradually find that antibiotics are easy to remain, cause allergic reactions and pollute the environment. Especially in recent years, the rapid increase of multi-drug resistant pathogens has become a serious threat to human society, and the development of new antibacterial agents has become an urgent task.

[0003] Antimicrobial peptides (AMPs) are a type of active peptides produced by biologic...

Claims

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