Polypeptide that specifically binds to β-catenin protein with high affinity and its application and synthesis method

An affinity and specific technology, applied in the direction of peptide/protein components, medical preparations containing active ingredients, peptides, etc., can solve the problem of lack of polypeptide β-catenin and BCL9, and achieve the induction of cell self-apoptosis and high yield efficiency. , the effect of inhibiting tumor growth

Active Publication Date: 2021-12-17
THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] There is no development of β-catenin and BCL9 inhibitors in the prior art, and there is no similar polypeptide that can inhibit the combination of β-catenin and BCL9, so the development of β-catenin and BCL9 inhibitors has great significance in cancer treatment. potential

Method used

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  • Polypeptide that specifically binds to β-catenin protein with high affinity and its application and synthesis method
  • Polypeptide that specifically binds to β-catenin protein with high affinity and its application and synthesis method
  • Polypeptide that specifically binds to β-catenin protein with high affinity and its application and synthesis method

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Embodiment Construction

[0019] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0020] The invention discloses a polypeptide specifically binding to β-catenin protein with high affinity. The amino acid sequence of the polypeptide is LEHRERSLQT(X1)RDIQRML(X2)P, wherein X1 is leucine (L), norleucine (NLE ) or homoleucine (HLE); X2 is phenylalanine (F), 1-naphthylalanine (1-NAL), 2-naphthylalanine (2-NAL), 2-anthracenyl Alanine (2-Anla) or 9-Anthracenylalanine (9-Anla).

[0021] The invention also discloses the application of a polypeptide that specifically binds to β-catenin protein with high affinity for inhibiting the growth of cancer cells, specifically for inhibiting the β-catenin / Wnt signaling pathway of cancer cells, inhibiting tumor growth, and inducing cell Self-apoptosis, more specifically, is used to inhibit the mutual binding of β-catenin and BCL9 in cancer cells, thereby inhibiting the β-catenin / Wnt signaling ...

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Abstract

The invention discloses a polypeptide that specifically binds to β-catenin protein with high affinity and its application and synthesis method. The amino acid sequence of the polypeptide is LEHRERSLQT(X1)RDIQRML(X2)P, wherein X1 is leucine, norleucine or homoleucine, X2 is phenylalanine, 1-naphthylalanine, 2-naphthylalanine, 2-anthrylalanine or 9-anthrylalanine; the polypeptide is used for inhibiting cancer cell growth; the polypeptide of the present invention can achieve a variety of tumor treatment goals; the polypeptide of the present invention inhibits the mutual binding of β-catenin protein and BCL9 in cancer cells, and inhibits the opening of the Wnt signaling pathway mediated by β-catenin protein, thereby inhibiting the Tumor tumor growth, induces cell self-apoptosis, and achieves the goal of tumor disease treatment; the synthesis method of this polypeptide is simple and easy to obtain, the final product yield is high, and has the potential of mass production, which has great potential for clinical transformation of drugs.

Description

technical field [0001] The invention belongs to the fields of medicinal chemistry and polypeptide chemistry, and in particular relates to a polypeptide specifically binding to β-catenin protein with high affinity and its application and synthesis method. Background technique [0002] Malignant tumors have become one of the major diseases that are increasingly common and seriously threaten human life and quality of life. Primary hepatic carcinoma is a malignant tumor caused by abnormal proliferation of liver cells. It is highly malignant and progresses rapidly, with poor prognosis and often endangers the lives of patients. Its death rate ranks fifth among malignant tumors in my country. Colorectal cancer and liver cancer are both digestive tract tumors, and are among the top 10 malignant tumors in my country. It can be seen that digestive tract tumors closely related to diet have seriously threatened the health of Chinese residents. At present, the clinical treatment methods...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/08A61K38/10A61P35/00
CPCC07K7/08A61P35/00A61K38/00
Inventor 何旺骁闫瑾
Owner THE FIRST AFFILIATED HOSPITAL OF MEDICAL COLLEGE OF XIAN JIAOTONG UNIV
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