A kind of water-soluble pegylated fischer carbene compound and preparation method thereof

A technology for PEGylation and compounding, which is applied in the field of water-soluble PEGylation Fischer carbene compounds and their preparation, can solve problems such as difficult derivatization of ligands, achieve simple synthesis methods, reduce toxicity, and increase water solubility
CN105801626BInactive Publication Date: 2018-03-06SHAANXI NORMAL UNIV +1
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHAANXI NORMAL UNIV
Publication Date
2018-03-06
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a water-soluble pegylation Fischer carbene complex. The structural formula of the complex can be seen in the description, wherein M represents Cr or Mo, R represents any one of H- and other three groups (please see the groups in the description), and n is an integer from 1 to 3. The complex is prepared from Fischer carbine and methoxypolyethylene glycol amino-acid ester hydrochloride under the catalysis of triethylamine at the room temperature, and the synthesis method is simple. Fischer carbine is modified by polyethylene glycol, and therefore the thermal stability and biological compatibility of Fischer carbine are improved, the toxicity of molecules is reduced, the water solubility of molecules is greatly improved, the combined complex can slowly release CO in a water phase, can rapidly release CO molecules under the irradiation of ultraviolet light and has good responsiveness to light, and a new road is developed for water-soluble CO molecule release.
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Description

technical field

[0001] The invention belongs to the technical field of synthetic medicine, in particular to a water-soluble pegylated Fischer carbene compound and a preparation method thereof. Background technique

[0002] CO has always been called the "silent killer", but with the small messenger molecules NO and H 2 With the development of S, people gradually realize that CO is also an important messenger molecule in the human body, which has many therapeutic effects such as relaxing cardiovascular, inhibiting malignant cell proliferation, protecting ischemia-reperfusion injury, anti-inflammation, and antibacterial; but CO has many therapeutic effects in Small solubility in water, easy to combine with hemoglobin in the body, difficult to quantitatively transport and other limitations. Although transition metal carbonyl compound-like carbon monoxide releasing molecules (CO Releasing Molecules, CO-RMs) have solved the limitation of transport, due to the strong hydrophobicit...

Claims

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