Genetic markers for pancreatic cancer screening

A technology of pancreatic cancer and gene expression level, applied in the field of gene markers for pancreatic cancer examination, can solve the problems of lack of typical clinical symptoms, low early diagnosis rate, poor prognosis, etc., and achieve dynamic monitoring of easy recurrence and metastasis, high sensitivity and specificity, good user experience

Active Publication Date: 2022-07-12
凤凰智药生物科技(苏州)有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the treatment of pancreatic cancer, early diagnosis is difficult, its onset is hidden, it lacks typical clinical symptoms, and its prognosis is extremely poor. Pancreatic cancer is highly aggressive and malignant, and the curative effects of surgery, chemotherapy and radiotherapy are not satisfactory. , the 1-year survival rate after surgery is less than 20%, and the 5-year survival rate is only 4%. The low early diagnosis rate and postoperative metastasis are the main reasons for the high mortality rate of pancreatic cancer

Method used

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  • Genetic markers for pancreatic cancer screening
  • Genetic markers for pancreatic cancer screening
  • Genetic markers for pancreatic cancer screening

Examples

Experimental program
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Effect test

Embodiment

[0083] The application of m1A regulated gene in the preparation of reagents or kits for pancreatic cancer diagnosis, monitoring, efficacy evaluation or metastasis and recurrence monitoring; Application in the kit;

[0084] The reagent or kit includes primers that specifically recognize ALKBH1;

[0085] High expression of ALKBH1 factor is associated with better prognosis of patients.

[0086] The expression of ALKBH1 factor was negatively correlated with the clinical grade of the subjects;

[0087] The expression of ALKBH1 factor is related to the physiological process of histone methylation.

[0088] The factor of m1A regulated gene can be applied to the diagnosis of pancreatic cancer. The ALKBH1 factor of the m1A regulated gene of the present invention is used for the diagnosis of pancreatic cancer, which can be detected earlier than clinical symptoms and signs, and provides a reference for doctors to intervene in advance.

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Abstract

The invention relates to the field of clinical diagnosis of pancreatic cancer, in particular to a gene marker for pancreatic cancer examination; the application of m1A regulatory gene in the preparation of reagents or kits for pancreatic cancer diagnosis, monitoring, efficacy evaluation or metastasis and recurrence monitoring; the invention further discloses The application of ALKBH1 factor in the preparation of reagents or kits for pancreatic cancer diagnosis, monitoring, efficacy evaluation or metastasis and recurrence monitoring is described. The invention has the advantages of safety and non-invasiveness in detecting pancreatic cancer, and even asymptomatic people have high acceptance of the detection; RNA sources are wide, and there is no detection blind spot in imaging; it is suitable for pancreatic cancer diagnosis, monitoring, curative effect evaluation or metastasis and recurrence monitoring, etc. The gene markers of the present invention can be combined with other clinical indicators to provide more accurate judgments for pancreatic cancer screening, diagnosis, treatment and prognosis.

Description

technical field [0001] The present invention relates to the field of clinical diagnosis of pancreatic cancer, in particular to a gene marker for pancreatic cancer examination. Background technique [0002] Pancreatic cancer is a common tumor of the digestive tract and one of the malignant tumors with the worst prognosis. According to the latest epidemiological survey, pancreatic cancer ranks fourth in the mortality rate of malignant tumors in developed countries such as Europe and the United States, and about 2.5 million people die of pancreatic cancer every year in the world. In the past 20 years, the incidence of pancreatic cancer in my country has continued to increase, and pancreatic cancer currently ranks fifth in the mortality rate of malignant tumors. [0003] Pancreatic adenocarcinoma (PAAD) is a gastrointestinal malignancy with a high degree of malignancy and is difficult to diagnose and treat. About 90% of them are ductal adenocarcinoma (PDAC) originating from the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/118C12Q2600/158C12Q2600/112
Inventor 郭文治郑清元张起尧何玉婷
Owner 凤凰智药生物科技(苏州)有限公司
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