Application of glucocorticoid in preparation of medicine for preventing and treating venous embolism

A glucocorticoid and venous embolism technology, applied in the field of medicine, can solve the problems of lack of treatment methods, rapid onset of pulmonary thromboembolism, poor prognosis of patients, etc., and achieve the effect of avoiding clinical complications

Inactive Publication Date: 2020-12-01
上海市闵行区中心医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rapid onset of pulmonary thromboembolism, the clinical diagnosis is difficult, and there is a lack of effective treatment methods, the prognosis of patients is often poor

Method used

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  • Application of glucocorticoid in preparation of medicine for preventing and treating venous embolism
  • Application of glucocorticoid in preparation of medicine for preventing and treating venous embolism

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0010] Effects of glucocorticoid (GC) on the activation of neutrophils and neutrophil extracellular traps (NETs)

[0011] Peripheral blood myelocytes were isolated and cultured, and treated with 100ng / mL lipopolysaccharide (LPS) for 4 hours to induce cell activation. On this basis, 0.1 μm and 0.25 μm GC were given respectively to detect the colony-forming ability of the cells and the formation ability of NETs in vitro.

[0012] like figure 1 As shown, after LPS treatment, the colony formation ability of neutrophils and the formation ability of NETs increased significantly, but the above increase decreased after GC treatment, and with the increase of GC treatment concentration, the colony formation of cells and the formation ability of NETs Formation inhibition was significant. This suggests that GC use inhibits the formation of NETs during neutrophil activation.

Embodiment 2

[0014] Effect of glucocorticoid (GC) on formation of neutrophil extracellular traps (NETs) in venous thromboembolism (VET) model

[0015] Use mice to construct an animal model of VTE, give GC treatment and no treatment respectively, kill the mice 7 days after the operation, collect lung tissue, make paraffin sections, and observe the shape and blood vessels of the mouse lung tissue by HE staining and changes in inflammatory cell infiltration.

[0016] like figure 2 As shown, the lung tissue of the control group and the mice treated with GC alone had no obvious pathological changes, the alveolar structure was complete, the size was uniform, there was no obvious exudation in the alveolar cavity, and there was no inflammatory cell infiltration in the lung interstitium. However, after VTE, the alveolar structure of the mice was irregular, different in size, and incomplete in structure, and obvious exudation was seen in the alveolar cavity of the above mice, and a large number of...

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Abstract

The invention discloses application of glucocorticoid in preparation of a medicine for preventing and treating venous embolism, and belongs to the technical field of medicines. According to the invention, the inhibition effect of GC on NETs is studied by utilizing clinically common medicine glucocorticoid (GC), so that the GC can be applied to new application of VTE treatment, a new strategy is provided for clinical antithrombotic treatment, the strategy can avoid clinical complications, and the method is safe and effective.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of glucocorticoids in the preparation of medicines for preventing and treating venous thrombosis. Background technique [0002] Pulmonary embolism is a disease caused by local blood supply disorders in the lungs caused by emboli formed in the body or entering the right ventricle through venous blood backflow and blocking the main pulmonary artery or branches. The formation of more likely to lead to pulmonary artery blockage. Due to the rapid onset of pulmonary thromboembolism, the difficulty of clinical diagnosis, and the lack of effective treatment methods, the prognosis of patients is often poor. The formation of neutrophil extracellular traps (neutrophilextracelluar traps, NETs) was first described as a novel defense mechanism during severe bacterial infection, and NETs have recently been found to play an important role in conditions such as ather...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61P7/02A61P11/00
CPCA61K31/573A61P7/02A61P11/00
Inventor 孙克玉解梓琛于水利
Owner 上海市闵行区中心医院
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