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Systems and methods for perfusing tissue distal to an arterial occlusion

A tissue, occlusion technology, applied in the system disclosed in publication 20160206816, at, in the field of catheter-based systems, capable of solving problems such as rough estimation

Active Publication Date: 2020-12-15
半透明系统有限责任公司
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

However, the above methods only provide rough estimates and are only used to predict outcome under optimal clinical conditions

Method used

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  • Systems and methods for perfusing tissue distal to an arterial occlusion
  • Systems and methods for perfusing tissue distal to an arterial occlusion
  • Systems and methods for perfusing tissue distal to an arterial occlusion

Examples

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Embodiment

[0136] Example: Using the example given above, assume we cool the temperature of the fluid to 25°C, and assume that the brain reaches this lower temperature very quickly. This will make the CMRO 2 reduced by about 75%, thus reducing the required [O 2 ] and thus lowered the ischemic threshold by 50%.

[0137]Tissue Conditioning: Tissues at risk of ischemic injury and secondary injury associated with ischemia can be conditioned by controlled and repeated reductions in tissue temperature distal to arterial occlusion under monitoring of the above parameters. Thus, arterial occlusion can be a pathological condition (eg, ischemic stroke / infarction), or artificial (eg, balloon occlusion). Pause between cooling phases to allow tissue temperature to return to warmer temperatures. By doing so, the tissue at risk can be prepared to better withstand the consequences of ischemia and reperfusion.

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Abstract

This application describes a method and device for safely, effectively, perfusing distal to occluded arteries, based on diagnostic information from the catheter-perfusion-system based on sensors, effectors, controllers and algorithms included, with particular attention to the specific characteristics of the tissue and the fluid. Key actionable physiological values for the tissue can be calculatedand derived. They include the auto-regulatory curve, with Upper and Lower limits of Auto regulation, vascular reserve, and collateral flow reserve and as auto-regulation exhaustion.

Description

Background technique [0001] The present application relates to systems and corresponding methods for perfusing tissue distal to occluded arteries, and more particularly to catheter-based systems that provide diagnostics based on the sensors, effectors, controllers, and processes that such systems include information, with particular attention to the specific characteristics of the tissue being perfused and the perfusion fluid. [0002] The present application relates to systems and corresponding methods for perfusing tissue distal to occluded arteries, and more particularly to catheter-based systems that provide diagnostics based on the sensors, effectors, controllers, and processes that such systems include information, with particular attention to the specific characteristics of the tissue being perfused and the perfusion fluid. [0003] Methods exist for assessing tissue condition following vessel occlusion. For example, angiographic assessment, provocation tests for temp...

Claims

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Application Information

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IPC IPC(8): A61M25/10A61B5/0205A61B5/026A61B5/00
CPCA61M2005/1726A61M5/1723A61M2205/332A61M2205/3334A61M2205/3344A61M2205/3368A61M2205/3379A61M2205/502A61M2205/52A61B5/6852A61B5/4064A61B5/02158A61M2205/505A61M5/16836
Inventor 约翰·皮勒-斯佩尔曼崔载
Owner 半透明系统有限责任公司
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