Edible esophageal ultrasonic coupling agent and preparation method thereof

An ultrasonic coupling agent and esophageal technology, applied in echo/ultrasonic imaging agents, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problems of unclear structure display, difficulty in inspection and imaging, etc., and achieve excellent adsorption performance, no Toxic side effect, low bulk density effect

Inactive Publication Date: 2020-12-22
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is mainly used for routine transthoracic echocardiography, where imaging is difficult, or the relevant structures are not clearly displayed

Method used

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  • Edible esophageal ultrasonic coupling agent and preparation method thereof
  • Edible esophageal ultrasonic coupling agent and preparation method thereof
  • Edible esophageal ultrasonic coupling agent and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Weighing raw materials: 20 parts of mint, 8 parts of cactus, 25 parts of honeysuckle, 13 parts of aloe, 40 parts of isatidis, 40 parts of corn flour, 15 parts of wheat starch;

[0030] (1) Wash mint, cactus, honeysuckle, and aloe, smash them, add 8 times of water to extract at 50°C for 2 hours, filter to obtain filtrate and filter residue; add 8 times of water to extract at 100°C for 1 hour, filter to obtain filtrate and filter residue, and combine Two filtrates were extracted.

[0031] (2) Take wheat starch and suspend it in a phosphate buffer solution with a pH value of 6.8 to obtain a starch slurry. The mixing ratio of starch and phosphate buffer solution is 1g: 5mL, put it in warm water at 50°C and preheat it for 10 minutes, then add the compound enzyme solution ( α-amylase and glucoamylase are mixed at a ratio of 1U:3U), the mixing volume ratio of compound enzyme solution and starch slurry is 1:5; after 8 hours of constant temperature enzymolysis at 50°C, absolute ...

Embodiment 2

[0034] Same as Example 1, the difference is that in step (1), directly add 10 times of water to extract for 2 hours at 100°C.

Embodiment 3

[0036] With embodiment 1, the difference is that step (2) wheat starch modification process is omitted.

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Abstract

The invention relates to the technical field of ultrasonic coupling agents, and in particular relates to an edible esophageal ultrasonic coupling agent. The edible esophageal ultrasonic coupling agentcomprises the following raw materials: mint, cactus, honeysuckle, aloe, radix isatidis, corn flour and wheat starch. A preparation method comprises the following steps of: taking mint, cactus, honeysuckle and aloe, adding water, and performing leaching to obtain leaching solution; modifying wheat starch with a compound enzyme to obtain modified starch; and, frying the prepared modified starch, corn flour and radix isatidis with slow fire to be slightly scorched, grinding into fine powder, mixing the fine powder with the leaching solution, and performing refining and extracting to obtain a gelpreparation, so as to obtain the edible esophageal ultrasonic coupling agent. The selected raw materials in the invention are all edible raw materials, are non-toxic and harmless to a human body, clear in ultrasonic imaging, proper in viscosity and free of greasiness; a probe is easy to slide; skin surface air is eliminated; the lubricating property is good; the probe is easy to spread; no corrosion or damage is caused to the ultrasonic probe; furthermore, the coupling agent has a disinfection and sterilization function; and, compared with a traditional common coupling agent, the coupling agent has a relatively wide application range.

Description

technical field [0001] The invention relates to the technical field of ultrasonic coupling agents, in particular to an edible esophageal ultrasonic coupling agent and a preparation method thereof. Background technique [0002] Medical ultrasonic coupling agent is an ultrasonic neutral medium that needs to be used in the process of ultrasonic diagnosis and treatment to fill or coat between the radiating surface of the probe and the human epidermis and mucous membrane to transmit sound waves. Ultrasonic coupling agent plays a role in determining the pros and cons and even success or failure in ultrasonic diagnosis and treatment operations. In clinical application, it not only plays the role of sound-transmitting medium, but also plays the role of lubricant. The clinical concern is not only its acoustic characteristics, but also the safety and effectiveness goals. Among them, the effectiveness mainly focuses on The effect of sound transmission, safety mainly focuses on the imp...

Claims

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Application Information

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IPC IPC(8): A61K49/22A61K36/886A61K36/896A61P31/02
CPCA61K36/195A61K36/315A61K36/33A61K36/355A61K36/534A61K36/886A61K36/896A61K49/22A61P31/02A61K2300/00
Inventor 付秀秀禹静唐国璋赵亮
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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