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Pharmaceutical composition for treating oral ulcers and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, hydroxyl compound active ingredients, etc., can solve the problems of easy recurrence of oral ulcers, poor patient compliance, long treatment time, etc., and achieve good clinical effect, quick effect, and effective treatment good effect

Active Publication Date: 2021-01-05
北京斯利安药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the above-mentioned medicines for the treatment of oral ulcers have a long treatment time, poor curative effect, easy recurrence after the treatment of oral ulcers, and have certain irritation during the treatment process, and the patient's compliance is relatively poor.

Method used

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  • Pharmaceutical composition for treating oral ulcers and preparation method thereof
  • Pharmaceutical composition for treating oral ulcers and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046]A pharmaceutical composition, calculated in parts by weight, comprising the following components: Coptis chinensis 10 parts, Cork 5 parts, Houttuynia cordata 5 parts, Kuditin 4 parts, Rehmannia glutinosa 5 parts, Light bamboo leaves 5 parts, Borneol 3 parts , 10 parts of Dragon's blood, 2 parts of Asarum, 5 parts of lemon, 3 parts of aloe, 3 parts of peppermint extract, 1 part of folic acid.

[0047]The preparation method of the above-mentioned pharmaceutical composition includes the following steps:

[0048]S1. Take the raw materials of Coptis, Phellodendron cortex, Houttuynia cordata, Kuh Di Ding, Rehmannia glutinosa, Phyllostachys edulis, Dragon Blood, Asarum, Lemon, Aloe, Peppermint extracts according to the ratio, and mix them with 20% ethanol as the weight percentage Solvent extraction of the drug substance, at 35°C warm immersion extraction, the number of extractions is 12 times, each extraction time is 1.5 hours, the amount of solvent each time is 11 times the total weight o...

Embodiment 2

[0052]A pharmaceutical composition, calculated in parts by weight, comprising the following components: 20 parts of Coptis, 12 parts of Cork, 10 parts of Houttuynia cordata, 7 parts of Kuditin, 10 parts of Rehmannia glutinosa, 10 parts of pale bamboo leaves, 6 parts of borneol , 15 parts of Dragon's blood, 5 parts of Asarum, 10 parts of lemon, 8 parts of aloe, 8 parts of peppermint extract, 5 parts of folic acid.

[0053]The preparation method of the above-mentioned pharmaceutical composition includes the following steps:

[0054]S1. Take the raw materials of Coptis, Phellodendron cortex, Houttuynia cordata, Kudi Ding, Rehmannia glutinosa, Phyllostachys edulis, Dragon Blood, Asarum, Lemon, Aloe, Peppermint extracts according to the ratio, mix them, and use 22% ethanol as the weight percentage. Solvent extraction of the drug substance, warm immersion extraction at 37°C, extraction times of 15 times, each extraction time 2.5 hours, each time the amount of solvent is 12 times the total weigh...

Embodiment 3

[0058]A pharmaceutical composition, based on parts by weight, comprising the following components: 15 parts of Coptis, 9 parts of Cork, 7 parts of Houttuynia cordata, 6 parts of Kuditin, 7 parts of Rehmannia glutinosa, 8 parts of pale bamboo leaves, 5 parts of borneol , 12 parts of Dragon's blood, 3 parts of Asarum, 7 parts of lemon, 6 parts of aloe vera, 6 parts of peppermint extract, 3 parts of folic acid.

[0059]The preparation method of the above-mentioned pharmaceutical composition includes the following steps:

[0060]S1. Take the raw materials of Coptis, Phellodendron, Houttuynia cordata, Kuh Di Ding, Radix Rehmanniae, Light Bamboo Leaf, Dragon Blood, Asarum, Lemon, Aloe, and Peppermint extracts according to the ratio, mix them, and use 21% ethanol as the weight percentage. Solvent extraction of the drug substance, warm immersion extraction at 36 ℃, extraction times is 14 times, each extraction time is 2 hours, each time the amount of solvent is 12 times the total weight of the dr...

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Abstract

The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for treating oral ulcers and a preparation method thereof. The pharmaceutical composition comprises the following components in parts by weight: 10-20 parts of rhizoma coptidis, 5-12 parts of cortex phellodendri, 5-10 parts of herba houttuyniae, 4-7 parts of herba corydalis bungeanae, 5-10 parts of radix rehmanniae recen, 5-10 parts of herba lophatheri, 3-6 parts of borneol, 10-15 parts of sanguis draxonis, 2-5 parts of herba asari, 5-10 parts of fructus citri limoniae, 3-8 parts of aloe, 3-8 parts of herba menthae extract and 1-5 parts of folic acid. The pharmaceutical composition has the advantages of having a good effect of treating the oral ulcers and a quick effect, avoiding recurrence of the oral ulcers, and being free of any irritation and free of toxic and side effects.

Description

Technical field[0001]The invention relates to the technical field of medicines, in particular to a pharmaceutical composition for treating oral ulcers and a preparation method thereof.Background technique[0002]Oral ulcers, commonly known as "aphthous sores", are localized ulcers of the oral mucosa characterized by periodic recurrence. They can heal themselves, but due to their periodic, recurring and self-limiting characteristics, they are generally difficult to heal in a short time. It is a common ulcerative injury disease that occurs in the oral mucosa. It is more common in the inner lip, tongue, belly of the tongue, buccal mucosa, vestibular sulcus, soft palate and other parts. The mucosa in these parts lacks keratinization layer or has poor keratinization. Tongue ulcers refer to oral ulcers that occur on the tongue and abdomen of the tongue. When oral ulcers attack, the pain is severe, and the local burning is obvious. In severe cases, it will affect eating and speaking, causing...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P1/02A61K31/045A61K31/519
CPCA61K36/718A61K36/756A61K36/78A61K36/66A61K36/804A61K36/899A61K31/045A61K36/889A61K36/896A61K36/268A61K36/752A61K36/886A61K36/534A61K31/519A61P1/02A61K2236/333A61K2236/55A61K2236/51A61K2300/00
Inventor 岳玉荣钟敏肖艳皎龚旭韩雅慧
Owner 北京斯利安药业有限公司
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