3-(5-imidazolyl)indole compounds and their preparation methods and applications
A compound and indole technology, applied in the field of 3-indole compounds and their preparation, can solve problems such as resistance
Active Publication Date: 2022-06-03
NANJING AGRICULTURAL UNIVERSITY
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Problems solved by technology
[0002] At present, several commercial fungicides such as carbendazim and boscalid have serious resistance problems, and it is urgent to create fungicides with new chemical structures and mechanisms of action
Method used
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Embodiment 1
[0024]
[0026] Yellow solid, yield: 94%. Mp: 128.9‑130.1℃.
Embodiment 2
[0030] White crystals; Yield: 84%. Mp: 110.1‑111.9℃.
Embodiment 3
3-(1-cyclohexyl-1-hydro-imidazol-5-base)-1-hydro-indole (compound 3c)
[0033] On the basis of Example 1, n-propylamine was replaced with cyclohexylamine to obtain compound 3c.
[0034] Light yellow solid; Yield: 49%. Mp: 159.4‑160.5℃.
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The invention discloses 3-(5-imidazolyl) indole compounds as shown in formula I. The 3-(5-imidazolyl)indole compound of the present invention has good bactericidal activity, can be applied to crop diseases caused by fungi, bacteria and viruses, and exhibits high-efficiency and / or broad-spectrum bactericidal activity. The invention also discloses the application of 3-(5-imidazolyl) indole compounds in killing pathogenic bacteria of crops.
Description
3-(5-imidazolyl) indole compound and preparation method and application thereof technical field The invention belongs to the field of agricultural fungicides, relate to 3-(5-imidazolyl) indole compounds and preparation method and application thereof use. Background technique At present, a plurality of commercial bactericides such as carbendazim, boscalid have occurred serious resistance problem, need to create new Bactericides with type chemical structure and mechanism of action. SUMMARY OF THE INVENTION The object of this invention is to design and synthesize a series of novel 3-(5-imidazolyl) indoles based on active natural products Compounds, the target compounds were tested for bactericidal activity, and the test results showed that the compounds were effective against a variety of common crop diseases. bacteria exhibited inhibitory activity. The object of the present invention is to be achieved through the following technical solutions: 3-(5-imidazolyl) ...
Claims
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IPC IPC(8): C07D403/04A01N43/50A01P3/00
CPCC07D403/04A01N43/50Y02A50/30
Inventor 张明智郭大乐高雅黄代钏谭隽杨章维华
Owner NANJING AGRICULTURAL UNIVERSITY