Application of ATXN7L3 in liver cancer diagnosis, treatment and prognosis

A liver cancer, prognosis judgment technology, applied in the field of biomedicine

Pending Publication Date: 2021-01-05
中国医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the expression and mechanism of ATXN7L3 in HCC have not been reported so far.

Method used

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  • Application of ATXN7L3 in liver cancer diagnosis, treatment and prognosis
  • Application of ATXN7L3 in liver cancer diagnosis, treatment and prognosis
  • Application of ATXN7L3 in liver cancer diagnosis, treatment and prognosis

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Embodiment Construction

[0027] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The experimental method that does not indicate specific condition in the embodiment, usually according to conventional conditions, such as the conditions described in textbooks and experimental guidelines, or according to the conditions suggested by the manufacturer, is well known or easy to know by those of ordinary skill in the art, the following implementation Examples are only preferred embodiments of the present invention, and do not limit the present invention. For those skilled in the art, the present invention can have various modifications and changes, and within the spirit and principles of the present invention, any modifications made , equivalent replacements, improvements, etc., should all be included within the protection scope of the present invention.

[0028] Example.

[0029] 1. Preparation of expression sequences.

[0030] T...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of ATXN7L3 in liver cancer diagnosis, treatment and prognosis. The invention provides a molecular marker ATXN7L3 related to liver cancer occurrence and development, and a liver cancer diagnosis product and means, and an expression level of the molecular marker is detected to judge whethera patient has risk of being affected with the liver cancer or not. In addition, the invention provides a medicine composition or method for treating the liver cancer, and the molecular marker is specifically up-regulated to treat the liver cancer. An experiment indicates that expression of the ATXN7L3 is compared in the cancer tissue and the para-carcinoma tissue of the HCC of a HCC clinical patient so as to discover that the ATXN7L3 is obviously under low expression in the HCC tissues of the cancer tissue. In addition, the expression of the ATXN7L3 is in positive correlation with the differentiation degree of the HCC tissue, i.e., an expression amount of the ATXN7L3 in the HCC tissue with the high differentiation degree is high. In addition, the expression of the ATXN7L3 shows negative correlation with the prognosis of the patient, i.e., the patient with ATXN7L3 low expression has a low general survival rate and short lifetime. In addition, through an in vivo and in vitro function experiment, the ATXN7L3 discovers that knockdown of ATXN7L3 protein expression can accelerate the multiplication capacity of HCC cells.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of ATXN7L3 in the diagnosis, treatment and prognosis of liver cancer. Background technique [0002] Liver cancer is the fourth leading cause of cancer-related death in the world. It is usually divided into primary liver cancer and secondary liver cancer. Primary liver cancer can be further divided into cholangiocarcinoma and hepatocellular carcinoma ( Hepatocellular carcinoma, HCC) and mixed liver cancer three types. Among the three, HCC is the most common histological subtype of primary liver cancer, with the characteristics of high recurrence, high metastasis, and poor prognosis. It is worth noting that the lethality of HCC ranks among the highest among all liver tumors. Although drugs including sorafenib are widely used in clinical treatment, their therapeutic effect is still very limited. Therefore, exploring new molecular mechanisms of HCC ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886A61K45/00A61P35/00
CPCC12Q1/6886A61K45/00A61P35/00C12Q2600/118C12Q2600/158C12Q2600/136
Inventor 赵越孙宁王春玉林琳王胜利
Owner 中国医科大学
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