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Application of glucosamine in preparation of medicine for treating non-alcoholic fatty liver disease

A technology of glucosamine and glucosamine hydrochloride, applied in the field of biomedicine, can solve problems such as toxicity and difficulty for patients to adhere to it for a long time

Pending Publication Date: 2021-01-08
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the drugs disclosed in the above-mentioned patents can regulate lipid metabolism, anti-oxidation, improve IR, etc., and more or less show certain therapeutic effects, there are no completely effective and certain drugs available for clinical use, and long-term use of these drugs has Certain toxicity, so it is difficult for patients to persist for a long time

Method used

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  • Application of glucosamine in preparation of medicine for treating non-alcoholic fatty liver disease
  • Application of glucosamine in preparation of medicine for treating non-alcoholic fatty liver disease
  • Application of glucosamine in preparation of medicine for treating non-alcoholic fatty liver disease

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Example 1, Experiment on the Effect of Glucosamine on Nonalcoholic Fatty Liver Disease

[0033] 1. Experimental protocol

[0034] 1.1 The main instruments and reagents of the experiment

[0035] Used main instrument and reagent in the experiment of the present invention are as shown in the following table:

[0036] Some equipment and reagents Manufacturer JJ500 electronic balance Changshu Shuangjie Testing Instrument Factory BT224S 1 / 10000 electronic balance Beijing Sartorius Scientific Instrument Co., Ltd. HVE-50 Automatic Autoclave Sterilizer Japan Hirayama Works AF103AS Snowflake Ice Machine Shanghai Scottsman Ice System Co., Ltd. DHG-9030A electric heating constant temperature blast drying oven Shanghai Yiheng Scientific Instrument Co., Ltd. Master-Q15 ultrapure water machine Shandong Boke Biological Industry Co., Ltd. Scieuitife-702 ultra-low temperature refrigerator American Thermo Technology Corporation...

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Abstract

The invention belongs to the technical field of biological medicines, and particularly relates to application of glucosamine in preparation of a medicine for treating non-alcoholic fatty liver disease. Experiments prove that the glucosamine with the daily dose of 300-600 mg / kg can improve insulin resistance, glycolipid metabolism disorder and liver lipid accumulation of mice with the non-alcoholicfatty liver disease, improve liver dysfunction, enhance oxidation resistance, and reduce body inflammation and serum endotoxin level. Therefore, the glucosamine has a certain treatment effect on thenon-alcoholic fatty liver disease.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the application of glucosamine in the preparation and treatment of non-alcoholic fatty drugs. Background technique [0002] Non-alcoholic fatty liver disease (NAFLD) is a metabolic stress-induced liver disease regulated by multiple factors such as metabolism, genes, environment, and gut microbes. Non-alcoholic simple fatty liver (NAFL), non-alcoholic steatohepatitis (NASH) and their related liver cirrhosis and hepatocellular carcinoma. With the prevalence of obesity and type 2 diabetes, NAFLD has become a worldwide public health problem, and 25%-30% of the world's population suffers from non-alcoholic fatty liver to varying degrees. In my country, due to changes in dietary structure and lifestyle, the incidence of NAFLD has gradually increased, and it has become the second largest liver disease after viral liver disease. A study conducted by the research team of...

Claims

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Application Information

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IPC IPC(8): A61K31/7008A61P1/16A61P3/10A61P5/50A61P35/00A61P3/06A61P39/06A61P29/00A61P39/02
CPCA61K31/7008A61P1/16A61P3/10A61P5/50A61P35/00A61P3/06A61P39/06A61P29/00A61P39/02
Inventor 苏政权曹华白研
Owner GUANGDONG PHARMA UNIV
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