Dentin desensitization paste based on biomimetic remineralization principle and preparation method of dentin desensitization paste

A technology of desensitizing paste and dentin, which is applied in the field of dentin desensitizing paste and its preparation based on the principle of bionic remineralization, can solve the problems of reducing sensitivity and high cost, and achieve inhibition of bacterial growth and good biophase capacitive effect

Pending Publication Date: 2021-01-08
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, there is laser treatment, which reduces sensitivity by irradiating the sensitive dentin surface with laser light, but its use is limited by its high cost

Method used

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  • Dentin desensitization paste based on biomimetic remineralization principle and preparation method of dentin desensitization paste
  • Dentin desensitization paste based on biomimetic remineralization principle and preparation method of dentin desensitization paste
  • Dentin desensitization paste based on biomimetic remineralization principle and preparation method of dentin desensitization paste

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] A dentin desensitization paste based on the principle of bionic remineralization, prepared by the following steps:

[0027] First, dissolve 5 grams of chitosan thickener in distilled water accounting for 37.25 grams of formula, stir and dissolve until gelatinous; take 1 gram of casein phosphopeptide, 7 grams of β-tricalcium phosphate, and 0.5 grams of sodium tripolyphosphate gram and 4 grams of calcium hydroxide are dissolved in the gel successively, after fully stirring, add 8 grams of hydroxypropyl-β-cyclodextrin and stir, and finally add 37.25 grams of distilled water, and fully stir to obtain 100 grams of dental composition . Divide and seal.

Embodiment 2

[0029] A dentin desensitization paste based on the principle of bionic remineralization, prepared by the following steps:

[0030] Dissolve the 8-hydroxymethylcellulose thickener in 44.7 grams of distilled water, stir and dissolve until gelatinous; take 7 grams of casein phosphopeptide, 1 gram of β-tricalcium phosphate, and 4 grams of sodium tripolyphosphate , 0.5 grams of calcium hydroxide were dissolved in the gel in turn, and after fully stirring, 5 grams of hydroxypropyl-β-cyclodextrin was added to stir, and finally 29.8 grams of distilled water was added, and fully stirred to obtain 100 grams of dental composition. Divide and seal.

Embodiment 3

[0032] A dentin desensitization paste based on the principle of bionic remineralization, prepared by the following steps:

[0033] Dissolve the thickener of 6 hydroxyethyl cellulose in 41.25 grams of distilled water, stir and dissolve until gelatinous; take 3 grams of casein phosphopeptide, 5 grams of β-tricalcium phosphate, and 1 gram of sodium tripolyphosphate 3 grams of calcium hydroxide were dissolved in the gel in turn, and after fully stirring, 7 grams of hydroxypropyl-β-cyclodextrin was added to stir, and finally 33.75 grams of distilled water was added, and fully stirred to obtain 100 grams of dental composition. Divide and seal.

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Abstract

The invention discloses dentin desensitization paste based on a biomimetic remineralization principle and a preparation method. The dentin desensitization paste is characterized by being prepared fromthe following raw material components in content (W/V): the dentin desensitization paste is relatively good in biocompatibility and has no adverse stimulation to oral tissues. Meanwhile, a high-concentration calcium-phosphate ion ratio can be kept on the surfaces of the teeth, further demineralization of the teeth is prevented, and the effects of protecting and strengthening the teeth are achieved after long-term use.

Description

technical field [0001] The invention relates to a pharmaceutical composition, especially a dentin desensitization paste, specifically a dentin desensitization paste based on the principle of dentin bionic remineralization and a preparation method thereof, desensitization paste Placed on the surface of sensitive dentin, the internal and external remineralization of dentin fibers can be formed through biomimetic remineralization, which can not only treat dentin sensitivity, but also have the effect of protecting teeth through the deposition and growth of remineralized substances inside and outside dentin collagen fibers. tooth function. Background technique [0002] Dentin sensitivity is a common and frequently-occurring disease in the field of stomatology, and it has a relatively high incidence in people of all ages. Dentin sensitivity is manifested as the sensitivity and pain of the affected tooth to cold, hot, sour, sweet and other stimuli. People with this symptom will fa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/17A61K9/06A61K47/40A61P1/02A61P25/00A61K33/08A61K33/42
CPCA61K38/1709A61K33/42A61K33/08A61K9/06A61K47/40A61K9/0063A61P1/02A61P25/00A61K2300/00
Inventor 于金华周洲李玉芝卞敏霞李泽汉景双林许涛叶宇叶夏颖
Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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