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Compounds Nudicatalpol A and Nudicatalpol B, and application thereof

A compound and drug technology, applied in the field of natural compounds and their medicinal functions, can solve problems such as adverse reactions of gout treatment drugs, and achieve the effect of relieving gout

Active Publication Date: 2021-01-08
诚简科技(深圳)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The object of the present invention is to address the problem of adverse reactions of gout treatment drugs in the prior art, to provide new compounds Nudicatalpol A and Nudicatalpol B extracted from Labiatae plant Nudicatalpol B and its preparation method and application

Method used

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  • Compounds Nudicatalpol A and Nudicatalpol B, and application thereof
  • Compounds Nudicatalpol A and Nudicatalpol B, and application thereof
  • Compounds Nudicatalpol A and Nudicatalpol B, and application thereof

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Embodiment 1

[0050]1. Extraction preparation and NMR identification of the compounds Nudicatalpol A and Nudicatapol B

[0051](1) Collect the aerial parts (including branches, leaves, flowers, and fruits) of P. vulgaris as raw materials, dry them naturally, and crush them.

[0052](2) Decoct the crushed raw materials with 10 times the amount of water for 2 hours, then use 8 times the amount of water to decoct for 1.5 hours, combine the decoction, filter, concentrate, and then pass through the water Elute with 50% ethanol aqueous solution with volume fraction, collect the eluate with volume fraction 50% ethanol aqueous solution, concentrate under reduced pressure, and concentrate under reduced pressure at a pressure of 10 kPa and a temperature of 60° C. to obtain a total extract.

[0053](3) Dissolve the total extract in water and let it stand. Take the supernatant and pass it through an MCI (polystyrene-based reversed-phase resin) column. Use methanol aqueous solution as the mobile phase, and use volume ...

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Abstract

The invention discloses compounds Nudicatalpol A and Nudicatalpol B, and a preparation method and application thereof. The chemical structural formulas of the compounds Nudicatalpol A and NudicatalpolB are shown as a formula (I), wherein in the formula (I) according to Nudicatalpol A, R1 is equal to H, and R2 is equal to CH3; and in the formula (I) according to Nudicatalpol B, R1 is equal to CH3,and R2 is equal to H. The novel natural compounds Nudicatalpol A and Nudicatalpol B extracted from Callicarpa nudiflora are combined with animal experiments to prove that the compounds have good effects of relieving hyperuricemia and gout, kidney and liver injury and arthritis caused by the hyperuricemia, are safe and effective, and have the value of being developed as corresponding therapeutic drugs.

Description

Technical field[0001]The invention belongs to the technical field of natural compounds and their medicinal functions, and specifically relates to the compounds Nudicatalpol A and Nudicatalpol B, and preparation methods and applications thereof.Background technique[0002]Gout is a chronic metabolic disease. It is caused by the disorder of purine metabolism in the human body, the concentration of blood uric acid exceeds the upper limit of normal, and the excretion of uric acid is reduced, resulting in excessive precipitation of urine blood crystals. Its main characteristics are recurrent acute and chronic arthritis and soft tissue damage caused by hyperuricemia and urate deposition, gouty nephropathy and joint deformities.[0003]The treatment of gout is based on chemical drugs. Commonly used are colchicine, allopurinol, allopurindiol, febuxostat, probenecid, benzbromarone, non-steroidal anti-inflammatory drugs, and glucocorticoids. And corticotropin and IL-1 inhibitors, but because of t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08A61P19/06A61P19/02A61P13/12A61P1/16A61P29/00A61K31/7048
CPCC07H17/04C07H1/08A61P19/06A61P19/02A61P13/12A61P1/16A61P29/00
Inventor 蓝蜀锋陈伟标马文玉文佳颖梁向平
Owner 诚简科技(深圳)有限公司
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