Application of tetrahydropyrimidine and derivatives thereof in prevention and/or treatment of intestinal diseases
A technology for ectoine and intestinal diseases, which is applied in the field of medicine, can solve the problems that have not been seen before with ectoine for preventing or treating intestinal diseases, and achieve the effect of increasing commercial value
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Embodiment 1
[0056] Example 1: Ectrahydropyrimidine and Hydroxyectoine Inhibit Body Weight Loss in Enteritis Mice
[0057] Sixty C57 mice were selected and randomly divided into 6 groups, namely normal control group, dextran sulfate sodium (dextran sulfatesodium, DSS) treatment group, DSS-ectoine high-dose group, DSS-ectoine low-dose group , DSS-hydroxy ectoine high dose group and DSS-hydroxy ectoine low dose group. The mice in DSS treatment group and DSS-ectoine or hydroxyectoine treatment group were treated with 2% DSS continuously for 10 days, and at the same time were treated with ectoine or hydroxyectoine orally, once a day. The dosage of ectoine low-dose group was 5 mg / kg, the dosage of ectoine high-dose group was 10 mg / kg; the dosage of hydroxy ectoine low-dose group was 1 mg / kg, and the dosage of hydroxyectoine high-dose group was 2 mg / kg. At the end of the treatment, the mice were sacrificed, and the effects of different treatments on the body weight of the enteritis mice were ev...
Embodiment 2
[0061] Example 2: Ectrahydropyrimidine and Hydroxyectoine Promote Intestinal Health in Mice with Enteritis
[0062] The treatment of the mice was the same as in Example 1, and the mice were sacrificed at the end of the treatment, and the effects of different treatments on the colon length of the enteritis mice were evaluated.
[0063] figure 2 Indicates the colon length of mice in the control group, DSS treatment group, high-dose DSS-ectoine group, low-dose DSS-ectoine group, high-dose DSS-hydroxy ectoine group and low-dose DSS-hydroxy ectoine group Variety.
[0064] Depend on figure 2 It can be seen that the administration of DSS leads to the significant shortening of the mouse colon, while the DSS-ectoine high-dose group, the DSS-ectoine low-dose group, the DSS-hydroxy ectoine high-dose group and the DSS-hydroxy ectoine low-dose group The colon of mice in the control group was significantly similar to that in the normal control group.
[0065] At the same time, the inv...
Embodiment 3
[0068] Example 3: Ectrahydropyrimidine and Hydroxyectoine Prolong the Survival Time of Irradiated Mice
[0069] 24 C57 mice were randomly divided into 6 groups, 4 in each group, and the irradiation dose was 13.0Gy (dose rate 170.0cGy / min); intraperitoneal administration 1 hour before irradiation, and the dose of ectoine low-dose group was 5mg / min. kg, the dose of ectoine high-dose group was 10 mg / kg; the dose of hydroxy ectoine low-dose group was 1 mg / kg, the dose of hydroxy ectoine high-dose group was 2 mg / kg, and the control group was given the same amount of normal saline. After 4 days of irradiation, the mice were sacrificed, and the intestinal sections were taken to examine the morphology of the inner wall.
[0070] The results showed that the intestinal villus in the control group was significantly reduced, the inner wall was severely damaged, and the cell infiltration was obvious, while the ectoine and hydroxyectoine treatment group had more intestinal villi, the inner ...
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