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Application of polyrhachis vicina roger extract in preparation of anti-cerebral ischemia drugs

A technique of imitating black spiny ants and anti-cerebral ischemia, which is applied in the field of traditional Chinese medicine, can solve the problems of long time of repeated application of drugs, limited administration methods, large dosage, etc., to improve the activity of blood-brain barrier damage, Prevention of cerebral ischemia, less pollution effect

Active Publication Date: 2021-01-22
GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing drugs are not suitable for repeated application due to their high price, limited administration methods, and many side effects, or the application is limited due to long medication time and large dosage.
However, there is no report on the application of the extract of the ants in the anti-cerebral ischemia.

Method used

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  • Application of polyrhachis vicina roger extract in preparation of anti-cerebral ischemia drugs
  • Application of polyrhachis vicina roger extract in preparation of anti-cerebral ischemia drugs
  • Application of polyrhachis vicina roger extract in preparation of anti-cerebral ischemia drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Example 1 Preparation of Pseudomonas spinosa extract

[0036] Take 1000g of Pseudomonas spinosa fine powder, add ethanol with a volume concentration of 95% and heat and reflux for extraction 3 times, 3L each time, each time the extraction pressure is -0.1MPa, the extraction temperature is 45°C, and the three extractions are combined, Ethanol was recovered under reduced pressure and concentrated to 1.0 g / mL to obtain the extract.

Embodiment 2

[0037] Example 2 Preparation of the extract of Pseudomonas spinosa ants

[0038] Take 1000g of Pseudomonas spinosa fine powder, add ethanol with a volume concentration of 75% and heat and reflux for extraction 3 times, 3L each time, each time the extraction pressure is -0.09MPa, and the extraction temperature is 62°C, combine the three extracts, reduce The ethanol was recovered under pressure and concentrated to 1.1 g / mL to obtain the extract.

Embodiment 3

[0039] Example 3 Preparation of Pseudomonas spinosa extract

[0040] Take 1000g of Pseudomonas spinosa fine powder, add petroleum ether (boiling range specification is 60-90°C) and heat and reflux for extraction twice, 3L each time, each time the extraction pressure is -0.09MPa, and the extraction temperature is 80°C. The two extracts were combined, petroleum ether was recovered under reduced pressure, and concentrated to 1.2 g / mL to obtain the extract.

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Abstract

The invention discloses an application of polyrhachis vicina roger extract in preparation of anti-cerebral ischemia drugs. An extraction method of the polyrhachis vicina roger extract comprises the following steps of taking polyrhachis vicina roger fine powder, adding an organic solvent, carrying out heating reflux extraction, and recovering the organic solvent under reduced pressure. It is foundfor the first time that the polyrhachis vicina roger extract has obvious activity of improving blood-brain barrier injury, is relatively high in lipid solubility, can easily pass through the blood-brain barrier of the brain, has the drug preparation potential of preparing anti-cerebral ischemia drugs or anti-cerebral ischemia functional drugs, provides a new material basis for developing innovative anti-cerebral ischemia drugs, and has the potential and huge social benefits and economic benefits.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of an extract of Pseudomonas spp. in the preparation of anti-cerebral ischemia drugs. Background technique [0002] Stroke includes ischemic stroke and hemorrhagic stroke, and ischemic stroke accounts for about 60%-80%. Ischemic stroke is a focal brain dysfunction caused by insufficient or interrupted local cerebral blood supply, oxygen supply, etc. The disease is a common clinical critical illness and frequently-occurring disease, often with a poor prognosis and high morbidity, disability and mortality. At present, there is still no effective method to treat or delay cerebral ischemic injury. Ischemia-reperfusion injury (IRI) refers to the pathological phenomenon in which tissue damage is aggravated after a certain period of ischemia and blood supply is restored. The brain tissue hypoxia and ischemia-reperfusion caused by ische...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/64A61P9/10
CPCA61K35/64A61P9/10
Inventor 韦洁何俊慧李冬梅韦桂宁何飞
Owner GUANGXI INST OF CHINESE MEDICINE & PHARMA SCI
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