Sodium new houttuyfonate and application of combination of sodium new houttuyfonate and cis-platinum in preparation of antitumor drugs

A new technology of houttuyniacin sodium and anti-tumor drugs, which can be applied in the directions of anti-tumor drugs, pharmaceutical formulations, drug combinations, etc., can solve problems such as aggravating the burden on organs

Active Publication Date: 2021-02-09
河南省医药科学研究院 +1
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  • Abstract
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  • Application Information

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Problems solved by technology

But generally speaking, cisplatin has relatively large renal, pancreatic and neurotoxicity, and long-term use will increase the burden on organs, so it is necessary to find new drugs to replace or reduce the toxic side effects of cisplatin

Method used

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  • Sodium new houttuyfonate and application of combination of sodium new houttuyfonate and cis-platinum in preparation of antitumor drugs
  • Sodium new houttuyfonate and application of combination of sodium new houttuyfonate and cis-platinum in preparation of antitumor drugs
  • Sodium new houttuyfonate and application of combination of sodium new houttuyfonate and cis-platinum in preparation of antitumor drugs

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Embodiment Construction

[0016] The technical solutions of the present invention will be further described in detail below in conjunction with the examples, but the protection scope of the present invention is not limited thereto.

[0017] Application test 1, the effect of neohouttuydin sodium and its combination with cisplatin in inhibiting colon cancer.

[0018] The growth inhibition rate of colon cancer cells (SW620) was detected by MTT assay.

[0019] (1) Experimental steps

[0020] (1.1) Drug preparation

[0021] Neohouttuydin sodium solution: take 1.0 mg of neohouttuydin sodium standard, add 50 μL of DMSO to dissolve, and use complete medium (ie DMEM medium containing 10% fetal bovine serum) to dilute to the desired concentration.

[0022] Cisplatin solution: Take 1.0 mg of cisplatin standard, add 100 μL of normal saline, and dilute to the desired concentration.

[0023] Negative control group: complete medium (DMEM medium containing 10% fetal bovine serum).

[0024] (1.2) Culture SW620 colo...

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Abstract

The invention provides sodium new houttuyfonate and application of sodium new houttuyfonate and cis-platinum in treatment of colon cancer, breast cancer, lymphoma, melanoma, lung cancer and other malignant tumors. A MTT method and a CCK-8 method are adopted to correspondingly determine sodium new houttuyfonate and inhibition effects of sodium new houttuyfonate and cis-platinum combined drug on various tumor cells (including SW620, A375, MCF-7, A549 and raji), and tests find that sodium new houttuyfonate and sodium new houttuyfonate and cis-platinum combined drug have significant inhibition effects on various tumor cells. Moreover, the combined medication shows an addition or synergistic effect, so that valuable theoretical and data support is provided for clinical treatment of malignant tumor diseases.

Description

technical field [0001] The invention belongs to the technical field of application of new houttuyfonate sodium, and in particular relates to a new houttuyfonate sodium and its combination with cisplatin in the preparation of anti-tumor drugs, such as new houttuybein sodium in inhibiting colon cancer, The application of malignant tumors such as breast cancer, lymphoma and melanoma, and the application of its combined use with cisplatin in inhibiting malignant tumors such as colon cancer, lung cancer, breast cancer and melanoma. Background technique [0002] Houttuynia cordata Thunb. is the fresh whole herb or dried aboveground part of Houttuynia cordata Thunb., a plant of the family Sanbaiaceae. It was first recorded in "Bielu of Famous Doctors". The key medicine for treating the lung and Yong." ([1] Liu Lian, Liu Teng, Peng Yongbo, Qiu Qiaochun. A compound pharmaceutical composition with anti-lymphoma effect and its application [P]. Guangdong Province: CN107095870B, 2019-05...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/243A61P35/00A61K31/185
CPCA61K31/185A61K33/243A61P35/00A61K2300/00Y02A50/30
Inventor 张壮丽高栗坤赵璐丹马方彭有梅邹敏陈慧平完迪迪范丹丹张丽果赵阳张长征张小俊杨洋李建波李娜郑立运赵志鸿张艳王东阳高元法
Owner 河南省医药科学研究院
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