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Immune checkpoint inhibitor co-expression vectors

A carrier system, immune regulation technology, applied in the direction of immunoglobulin, introduction of foreign genetic material using carrier, vaccine, etc.

Pending Publication Date: 2021-02-09
GRITSTONE BIO INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In addition to the challenges of current neoantigen prediction methods, there are certain challenges with the available vector systems for neoantigen delivery in humans, many of which are derived from human

Method used

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  • Immune checkpoint inhibitor co-expression vectors
  • Immune checkpoint inhibitor co-expression vectors

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Embodiment Construction

[0142] I. Definition

[0143] Generally, the terms used in the claims and specification are intended to be interpreted to have their ordinary meanings as understood by those of ordinary skill in the art. For clarity, certain terms are defined below. In the event of a conflict between the ordinary meaning and the provided definition, the provided definition shall apply.

[0144] As used herein, the term "antigen" is a substance that induces an immune response. An antigen can be a neoantigen. Antigens may be "consensus antigens," which are antigens found in a particular population (eg, a particular population of cancer patients).

[0145] As used herein, the term "neoantigen" is an antigen that has at least one alteration that makes it different from the corresponding wild-type antigen, for example via a mutation in a tumor cell or a post-translational modification specific for a tumor cell. Neoantigens can include polypeptide sequences or nucleotide sequences. Mutations ma...

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Abstract

Disclosed herein are vectors that include antigen-encoding nucleic acid sequences and co-express immune modulators. Also disclosed are nucleotides, cells, and methods associated with the vectors including their use as vaccines.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Application No. 62 / 675,624, filed May 23, 2018, which is hereby incorporated by reference in its entirety for all purposes. [0003] sequence listing [0004] This application contains a Sequence Listing, which has been filed electronically in ASCII format, and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 22, 2019, is named GSO_018_WO_Sequence_Listing.txt and is 422,185 bytes in size. Background technique [0005] Therapeutic vaccines based on tumor-specific antigens hold great promise as a new generation of personalized cancer immunotherapy. 1–3 For example, cancers with high mutational burdens, such as non-small cell lung cancer (NSCLC) and melanoma, are particularly attractive targets for such therapies given the relatively high likelihood of neoantigen production. 4,5 Early evidence suggests that neoantigen-based vaccin...

Claims

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Application Information

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IPC IPC(8): A61K39/00C12N15/85
CPCA61K39/12C12N2740/14034C12N2710/16134C12N2710/16234C12N2760/16134C12N2730/10134C12N2770/24234A61K2039/70A61K2039/6037A61K2039/605A61K2039/572A61K2039/575C12N2740/16334C12N2710/20034A61K39/001191A61K39/001188A61K2039/6031C12N2710/10343C12N2740/16134C12N2740/16234C12N2770/36143A61P35/00C07K14/70539C07K14/70596C07K14/705C12N15/86C07K16/2818C12Q1/6827A61P31/16A61P31/20C12N2770/24143A61K2039/505A61K39/0012
Inventor W·布莱尔K·朱斯L·吉特林C·D·斯卡伦A·R·拉帕波特G·M·格罗滕布雷格
Owner GRITSTONE BIO INC
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