A kind of bone repair scaffold for treating tumor and its manufacturing method
A manufacturing method and bone repair technology, applied in the field of biomedical materials, can solve the problems of tumor recurrence, increasing the economic burden of patients' families, and metastatic lesions.
Active Publication Date: 2022-07-26
HANGZHOU DIANZI UNIV
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Problems solved by technology
For many patients with bone tumors, after the tumor is resected, some tumor cells may remain around the resected tumor, which may form metastatic lesions and lead to tumor recurrence
This is not only a physical and psychological torture to the patient, but also increases the financial burden on the patient's family
Method used
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Embodiment
[0047] For the bone repair scaffold for tumor treatment manufactured in this example, for the selected materials, hydroxyapatite is used for the loading unit, loading frame, and protective layer, 5% dilute hydrochloric acid is used as the heating material in the loading unit, and 5% dilute hydrochloric acid is used for the heating material in the loading frame. The heating material is calcium oxide.
[0048] 1) Mix the hydroxyapatite and the hydrogel solution 3:2 uniformly as required to obtain a uniformly dispersed bio-ink 1. The hydroxyapatite, PCL, and dichloromethane were uniformly mixed at a ratio of 9:1:10 to obtain bioink 2.
[0049] 2) Add bio-ink 1 to the 3D printer, design the model of the loading unit, the shape of a cuboid, the surface opening area accounts for 30% of one side of the loading unit, and the six sides are open, and use the 3D printer to manufacture the loading unit. The loading unit is then dried in an oven at 80°C for 6 hours, and the loading unit i...
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Abstract
The invention discloses a bone repair scaffold for treating tumors and a manufacturing method thereof. The scaffold is composed of a loading unit, a loading frame surrounding the loading unit, and an outer protective layer outside the loading frame. The loading unit includes The hollow three-dimensional frame structure and the heating material carried inside and the hole plugs on the surface of the three-dimensional frame. The carrier frame has a porous structure, wraps the entire carrier unit, the porosity is 10%-40%, and the shape of the hole can be square, circular, or the like. The heating materials carried in the load-carrying unit and the load-carrying frame are different, and a large amount of heat is released by the contact and reaction of the two materials. The invention can not only control the heat release time of the stent in the body, but also adjust the rate and duration of heat release by adjusting the porosity of the material-carrying stent, so that the stent continues to heat up, and the remaining tumor cells outside the stent are killed by high temperature. die. At the same time, it can also promote the repair of bone defects.
Description
technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a bone repair scaffold for treating tumors and a manufacturing method thereof. Background technique [0002] At present, the rapid regeneration and repair of bone defects is a hot topic in related fields and a difficult problem in clinical medicine. For the treatment of bone injury after bone tumor resection, we are always looking for faster and better methods. In the past, people mainly used metals, alloys or biologically inert ceramic artificial materials with high mechanical strength to repair, fill, and replace human bone defects, but these fillers only played the role of mechanical support. Now, people have begun to study degradable biomaterials, which have excellent mechanical properties and good biological activity, and can also promote the self-healing of bone injuries while providing mechanical support. For many patients with bone tumors, after the tumor i...
Claims
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IPC IPC(8): A61L27/02A61L27/12A61L27/50A61L27/54A61L27/56A61L27/58A61F2/30B33Y80/00
CPCA61L27/12A61L27/025A61L27/50A61L27/56A61L27/54A61L27/58A61F2/30771A61F2/30942B33Y80/00A61L2430/02A61L2300/416A61F2002/30784A61F2002/30985
Inventor 邵惠锋年志恒贺永段王平景卓荦龚友平刘海强陈慧鹏李文欣
Owner HANGZHOU DIANZI UNIV