Vaccines and compositions based on S antigen protein of SARS-CoV-2

A sars-cov-2, protein technology, applied in the direction of DNA / RNA vaccination, vaccines, virus antigen components, etc.
CN112480217AActive Publication Date: 2021-03-12GUANGZHOU ARGORNA BIOPHARMACEUTICALS CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
GUANGZHOU ARGORNA BIOPHARMACEUTICALS CO LTD
Publication Date
2021-03-12

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Abstract

The present disclosure provides vaccines and compositions based on S antigen proteins of SARS-CoV-2, and specifically relates to recombinant SARS-CoV-2 spike proteins (S proteins) or antigenic fragments thereof, and mRNAs encoding the same. The present disclosure also relates to mRNA comprising a sequence selected from any one of SEQ ID NO. 44 to 47. The present disclosure further relates to mRNA-vector particles, such as lipid nanoparticles (LNPs), comprising the aforementioned mRNAs and compositions, such as vaccine compositions.
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Description

technical field

[0001] The disclosure belongs to the technical field of biomedicine and vaccines, and in particular relates to vaccines and compositions against novel coronavirus SARS-CoV-2. Background technique

[0002] Coronaviridae virus is an enveloped single-stranded positive-sense RNA virus with the largest genome among RNA viruses, up to 27-32kb. Coronaviridae is divided into 4 genera α, β, γ and δ, among which α and β genera are susceptible to mammals, while γ and δ genera mainly infect poultry. So far, seven human coronaviruses have been discovered, such as the novel coronavirus (Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2). SARS-CoV-2 is highly pathogenic and poses a serious threat to public health. Since the beginning of 2020, the novel coronavirus pneumonia epidemic caused by SARS-CoV-2 has swept the world. As of September 2020, the cumulative number of confirmed patients worldwide has exceeded 30 million, posing a huge threat to global public h...

Claims

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