Application of hematoporphyrin derivative combined with chemical drug in treatment of osteosarcoma
A derivative, the technology of hematoporphyrin, which is applied in the field of medicine to increase the sensitivity of chemotherapy drugs, can solve the problems of low polarity and limited application of hematoporphyrin, and achieve the effect of broad application prospects and easy mastery
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Embodiment 1
[0037] Synthesis of Hematoporphyrin Derivative A2
[0038] Hematoporphyrin and verapamil fragments (3,4-dimethoxyphenethylamine) are catalyzed by BOP to synthesize the target product, namely hematoporphyrin derivative A2, through amide condensation reaction. The synthesis process is as follows:
[0039]
[0040] The specific operation is:
[0041] Dissolve 0.5 mmol of hematoporphyrin in a reaction vessel filled with 30 mL of dimethylformamide (DMF), and add 4 mmol of 3,4-dimethoxyphenethylamine and 0.5 mmol of benzotriazol-1-yloxy base tris(dimethylamino)phosphonium hexafluorophosphate (BOP), stirred at room temperature for 3 hours, and TLC detected the reaction progress; Precipitate a solid; suction filter the precipitated solid and dry to obtain a crude product; dissolve the crude product in ethyl acetate, add 200-300 mesh silica gel in an amount equivalent to three times the mass of the crude product, and vacuum rotary evaporate ethyl acetate Esters; in silica gel col...
Embodiment 2
[0045] CCK8 kit detects the activity of compound A2 and chemotherapeutic drugs in inhibiting the proliferation of osteosarcoma cells
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