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ACE inhibitory peptide and application thereof

A technology for inhibiting peptides and uses, applied in the field of bioactive peptides, can solve problems such as taste disturbance, elevated blood potassium levels, allergic reactions, etc., achieve high ACE inhibitory activity, inhibit cell apoptosis, reduce MDA content and ROS levels Effect

Active Publication Date: 2021-03-19
百益美恒(北京)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, common chemically synthesized antihypertensive drugs include captopril, lisinopril, enalapril, etc. However, it is found clinically that these drugs can cause adverse effects such as elevated blood potassium levels, taste disturbance, cough, and allergic reactions reaction

Method used

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  • ACE inhibitory peptide and application thereof
  • ACE inhibitory peptide and application thereof
  • ACE inhibitory peptide and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] 1 Materials and Instruments

[0075] 1.1 Materials

[0076] Purple mussels were purchased from Gouqi Island, Shengsi, Zhoushan.

[0077] 1.2 Main reagents

[0078] Table 1 Main Reagents

[0079]

[0080]

[0081] 1.3 Instruments

[0082] Table 2 Instruments

[0083]

[0084] 2 methods

[0085] 2.1 A preparation method of purple mytilus ACE inhibitory peptide, comprising:

[0086] 1) Firstly shell the blue mussel, pick the meat, remove the silk, and then grind it, then degrease it with ethyl acetate according to the ratio of material to liquid 1:5 (w / v) for 48 hours, and vacuum the blue mussel after degreasing. After removing ethyl acetate by suction filtration, drying and pulverizing to obtain defatted blue mussels;

[0087] 2) Adjust the pH of the 20 mg / mL defatted blue mussel solution to 2.0 with 1M HCl, add pepsin according to the enzyme:substrate (w / w) ratio of 1:50, mix well and stir at 37°C for 2 hours; then with saturated NaHCO 3 solution (0.9M)...

Embodiment 2

[0099] The difference from Example 1 lies in: a preparation method of ACE inhibitory peptide from purple mytilus, step 2) using a defatted purple mytilus solution with a concentration of 5 mg / mL.

Embodiment 3

[0101] The difference from Example 1 lies in: a preparation method of ACE inhibitory peptide from purple mytilus, step 2) using a defatted purple mytilus solution with a concentration of 10 mg / mL.

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PUM

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Abstract

The invention provides an ACE inhibitory peptide and an application thereof, and belongs to the technical field of bioactive peptides. The ACE inhibitory peptide has amino acid sequences of Met-Phe-Arg or Met-Phe-Val or Phe-Val or Lys-Pro or Gln-Pro or Gln-Val-Lys or Ile-Lys or Tyr-Lys-Val or Ile-Arg-Lys or Met-Leu-Lys-Val or Asn-Phe-Arg-Pro-Gln or Tyr-Glu-Gly-Asp-Pro or Trp-Phe or Gly-Pro-Glu orSer-Trp-Ile-Ser-Ser or Ser-Val-Glu-Trp-Lys or Phe-Lys-Trp-His. The ACE inhibitory peptide of the present invention is used for preparing antihypertensive products and / or products for preventing and / ortreating hypertension.

Description

technical field [0001] The invention belongs to the technical field of bioactive peptides, and in particular relates to an ACE inhibitory peptide and its application. Background technique [0002] Hypertension is a major risk factor for stroke, myocardial infarction, heart failure, and chronic kidney disease. According to statistics, the number of deaths caused by hypertension in the world accounts for about 12.8% of the total number of deaths every year. At present, the common chemically synthesized antihypertensive drugs include captopril, lisinopril, enalapril, etc. However, it has been found clinically that these drugs can cause adverse effects such as elevated blood potassium levels, taste disturbance, cough, and allergic reactions. reaction. Compared with chemically synthesized ACE inhibitors, food-derived bioactive peptides have many advantages, such as relatively mild, safe and easy to absorb. At the same time, these peptides often have anti-oxidation, anti-aging, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/062C07K5/065C07K5/068C07K5/072C07K5/078C07K5/083C07K5/087C07K5/103C07K5/107C07K7/06C07K1/36C07K1/34C07K1/20C07K1/18C07K1/16C12P21/06A23L33/18A61K38/05A61K38/06A61K38/07A61K38/08A61P9/12A61P39/06
CPCC07K5/081C07K5/06078C07K5/06086C07K5/06104C07K5/06034C07K5/0812C07K5/0808C07K5/1013C07K7/06C07K5/06156C07K5/0806C07K5/1016C12P21/06A61P9/12A61P39/06A61K38/00C07K5/0819C07K14/43509
Inventor 王斌迟长凤潘筱鸯赵玉勤
Owner 百益美恒(北京)科技有限公司
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