Acetes chinensis protein antigypertensive peptide and preparation method and application thereof

Abstract

the invention discloses a Chinese shrimp protein isallobaric peptide and preparing method and application in the ocean biological technological domain, which is characterized by the following: separating and purifying the isallobaric peptide with 6 amino acids; possessing inhibiting activity of high ACE; proceeding chemical synthesis for shorted-peptide of three 6-amino acids; sieving 12-sequence short peptide with excellent ACE inhibiting activity.

Description

[0001] This application is a divisional application of No. 200410075836.4 patent application with the same name. (1) Technical field [0002] The invention relates to the separation and purification of an antihypertensive peptide with a new amino acid sequence from an enzymatic hydrolysis product of Chinese hairy shrimp (Accedes chinensis), a preparation method and application thereof, and belongs to the technical field of marine biology. (2) Background technology [0003] Short peptides obtained by partial enzymatic hydrolysis of food proteins have attracted more and more attention from food scientists. These short peptides have various activities, such as: enhancing immunity, increasing nutrient absorption rate, antihypertensive activity. Proteins with these activities have been purified from food protein hydrolysates. These peptides are inactive within the protein sequence and are only active when released from the protein by enzymatic hydrolysis or food processing. [0...

AI Technical Summary

Problems solved by technology

Although artificially synthesized ACE inhibitors have obvious blood pressure lowering effects, but the side effects are too large, so it is now necessary to find safer, novel and efficient drugs for the treatment of hypertension

Now, different proteins are hydrolyzed by different enzymes, and many ACE-inhibiting short peptides are found in the hydrolyzate. These protein resources include milk protein, soybean protein, egg protein, chicken protein, marine fish protein, algae etc. Up to now, more than 200 enzymatically active peptides with ACE inhibitory activity have been reported, but the reported ACE-inhibiting short peptides are mainly derived from hydrolyzates of land proteins, and reports from marine protein hydrolysates are relatively rare. Therefore, in the future, marine biological protein hydrolyzate will become an important source for screening new ACE inhibitory peptides in the future

[0005] Hairy shrimp is a low-value-added marine protein resource in the waters of Bohai Bay in my country. The annual catch reaches 300,000 tons. So far, there is no effective development and utilization. It is only dried to make shrimp skin or shrimp paste. Additional products low value

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