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Combination of lactobacilli for relief of irritable bowel syndrome and for relief of other gastrointestinal disorders

A technology for irritable bowel syndrome and gastrointestinal diseases, applied in the field of gastrointestinal diseases, can solve problems such as difficulty in interpretation of research results

Pending Publication Date: 2021-04-13
BIO K PLUS INT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Strong placebo effects, psychological factors, and gender effects make interpretation of findings difficult (Ford and Moayyedi, 2010; Lyra et al., 2016; Moayyedi et al., 2010)

Method used

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  • Combination of lactobacilli for relief of irritable bowel syndrome and for relief of other gastrointestinal disorders
  • Combination of lactobacilli for relief of irritable bowel syndrome and for relief of other gastrointestinal disorders
  • Combination of lactobacilli for relief of irritable bowel syndrome and for relief of other gastrointestinal disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1: Lactobacillus acidophilus Lactobacillus casei and Lactobacillus rhamnosus Improvement of QOL and symptoms of IBS-C, IBS-D: a double-blind, randomized, placebo-controlled study

[0037] The purpose of this clinical trial was to evaluate the proprietary probiotic product Lactobacillus acidophilus +Lactobacillus casei +Lactobacillus rhamnosus Relief of specific IBS-related symptoms, improvement of quality of life, effects on stool consistency and frequency, in irritable bowel syndrome with constipation (IBS-C), diarrhea (IBS-D) and mixed (IBS-M) subtypes Adequate remission (AR) effect in otherwise healthy adults with symptoms.

[0038] Materials and methods

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PUM

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Abstract

Described herein are compositions and methods relating to the use of a combination of live lactobacilli bacteria, particularly live Lactobacillus acidophilus, live Lactobacillus casei, and live Lactobacillus rhamnosus, for the relief of undesirable gastrointestinal health problems such as irritable bowel syndrome (IBS), abdominal pain, abdominal discomfort, bloating, liquid stools and constipation. The combination of live lactobacilli bacteria can also be used for improving quality of life of a subject suffering from IBS, for the relief of IBS, and / or for the prevention and / or treatment of IBS.

Description

technical field [0001] The present invention relates to the field of gastrointestinal disorders, and more particularly to the use of live Lactobacillus bacterial combinations in the relief of undesirable gastrointestinal health problems such as irritable bowel syndrome (IBS), abdominal pain, abdominal discomfort, bloating, liquid stools and constipation the use of. Background technique [0002] Irritable bowel syndrome (IBS) is a chronic relapsing gastrointestinal disorder that affects 5-20% of the US population. A number of risk factors for IBS have been identified, including female gender, psychological issues, stress, food intolerances, and small intestinal bacterial overgrowth (Aagaard et al., 2013). The main symptoms of IBS include abdominal pain, bloating, and changes in bowel habits (Aagaard et al., 2013). The pathophysiology of this syndrome is well-defined, and the syndrome is not accompanied by structural abnormalities of the gut. The quality of life of individu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/747A61K38/00A61P1/00A61P1/12A61P1/14
CPCA61K35/747A61P1/00A61P1/12A61P1/14A61K38/011A61K38/018A61K2300/00A23L33/19A23L33/135A23L33/185A61K9/48
Inventor S·卡里埃
Owner BIO K PLUS INT