Use of zine hyaluronate against peptic ulcer

Zinc hyaluronate, anti-digestion technology, applied in the preparation of anti-peptic ulcer composition, treatment and prevention of peptic ulcer, zinc hyaluronate prevents re-infection after healing of peptic ulcer, preparation of this composition , Zinc complex field of hyaluronic acid, able to solve problems such as limited quantity

Zinc hyaluronate, anti-digestion technology, applied in the preparation of anti-peptic ulcer composition, treatment and prevention of peptic ulcer, zinc hyaluronate prevents re-infection after healing of peptic ulcer, preparation of this composition , Zinc complex field of hyaluronic acid, able to solve problems such as limited quantity

CN1126548CInactive Publication Date: 2003-11-05RICHTER GEDEON VEGYESZETI GYAR RT
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  • Use of zine hyaluronate against peptic ulcer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1 Preparation of 1.0% zinc hyaluronate solution

[0022] Under constant stirring, sodium hyaluronate (1.0 g) was swelled in 30 ml of water, 18.75 ml of 0.1 molar zinc chloride solution was added, and the solution was added to 100 ml with distilled water.

[0023] It is used to prepare the characteristics of sodium hyaluronate containing the following zinc hyaluronate

Zinc Hyaluronate

(I)

Zinc Hyaluronate

(II)

Zinc Hyaluronate

(III)

Hyaluronic acid

(M)

Sodium hyaluronate

Content

97.77

97.50

99.07

96.25

Molecular weight

750,000

900,000

1,200,000

982,000

Protein content

0.018％

0.032％

0.019％

0.16％

Viscosity

14.0dl / g

16.0dl / g

19.0dl / g

17.0dl / g

UV absorption

A 0.2％ 260nm

0.017

0.018

0.016

0.045

[0024]For the test, the used am...

Embodiment 2

[0244] Tablets containing 10mg active ingredient and weighing 200mg Zinc hyaluronate 10mg anhydrous lactose 106mg pregelatinized starch (Lycatos PGS) 6mg corn starch (Amylum maydis) 40mg microcrystalline cellulose (Avicel PH102) 30mg silicon dioxide gas Gel 200 1mg

[0245] Talc 6mg

[0246] Magnesium stearate 1mg

[0247] After the active ingredients and additives are subjected to conventional wet granulation, the mixture is compressed into tablets weighing 200 mg. Example 3

Embodiment 3

[0248] A pharmaceutical composition containing 10 mg of active ingredients and weighing 200 mg, wherein the composition is made into a pill for use in a sachet, vial or capsule.

[0249] Zinc Hyaluronate 10mg

[0250] Lactose 95mg

[0251] Microcrystalline cellulose (Avicel PH101) 95mg

[0252] The active ingredients and additives are made into pellets using known methods, such as in a vortex granulator. Pack the pellets in sachets, vials, or capsules. Example 4

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Abstract

The invention relates to pharmaceutical compositions against peptic ulcer as well as to a method of treating peptic ulcer. The compositions contain and the method of treatment employs zinc hyaluronate as an active ingredient having a molecular weight in the range of 500,000 to 1,200,000 daltons.

Description

Technical field [0001] The present invention relates to a zinc complex (complex) containing hyaluronic acid, a pharmaceutical composition with anti-peptic ulcer effect, and a method for preparing such a composition. [0002] The present invention also relates to the zinc complex (complex) of hyaluronic acid, that is, the use of zinc hyaluronate in the preparation of an anti-peptic ulcer composition, and a method for treating and preventing peptic ulcer. The present invention also relates to the use of zinc hyaluronate to prevent re-infection of peptic ulcer after healing. Background technique [0003] It is known that the macromolecular compound called hyaluronic acid, which usually exists in the form of its sodium salt, has a history of more than 50 years. Meyer et al. ["Journal of Biological Chemistry" (J.Biol.Chem.) 107 , 629 (1934)] first described hyaluronic acid, which is a highly viscous natural glucosamine containing variable β-1,3 glucuronic acid and β-1,4 glucosamine mo...

Claims

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Application Information

Patent Timeline
05 Nov 2003
Publication
CN1126548C
IPC
A61K31/715; A61K31/728; A61K47/48; A61P1/04
CPC
A61K31/728; A61K47/61; A61P1/00; A61P1/04; A61K31/715
Inventors
拉斯洛·苏波尼; 亚诺什·伊利斯