Use of zine hyaluronate against peptic ulcer
Zinc hyaluronate, anti-digestion technology, applied in the preparation of anti-peptic ulcer composition, treatment and prevention of peptic ulcer, zinc hyaluronate prevents re-infection after healing of peptic ulcer, preparation of this composition , Zinc complex field of hyaluronic acid, able to solve problems such as limited quantity
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Embodiment 1
[0021] Example 1 Preparation of 1.0% zinc hyaluronate solution
[0022] Under constant stirring, sodium hyaluronate (1.0 g) was swelled in 30 ml of water, 18.75 ml of 0.1 molar zinc chloride solution was added, and the solution was added to 100 ml with distilled water.
[0023] It is used to prepare the characteristics of sodium hyaluronate containing the following zinc hyaluronate
Zinc Hyaluronate
(I)
Zinc Hyaluronate
(II)
Zinc Hyaluronate
(III)
Hyaluronic acid
(M)
Sodium hyaluronate
Content
97.77
97.50
99.07
96.25
Molecular weight
750,000
900,000
1,200,000
982,000
Protein content
0.018%
0.032%
0.019%
0.16%
Viscosity
14.0dl / g
16.0dl / g
19.0dl / g
17.0dl / g
UV absorption
A 0.2% 260nm
0.017
0.018
0.016
0.045
[0024]For the test, the used am...
Embodiment 2
[0244] Tablets containing 10mg active ingredient and weighing 200mg Zinc hyaluronate 10mg anhydrous lactose 106mg pregelatinized starch (Lycatos PGS) 6mg corn starch (Amylum maydis) 40mg microcrystalline cellulose (Avicel PH102) 30mg silicon dioxide gas Gel 200 1mg
[0245] Talc 6mg
[0246] Magnesium stearate 1mg
[0247] After the active ingredients and additives are subjected to conventional wet granulation, the mixture is compressed into tablets weighing 200 mg. Example 3
Embodiment 3
[0248] A pharmaceutical composition containing 10 mg of active ingredients and weighing 200 mg, wherein the composition is made into a pill for use in a sachet, vial or capsule.
[0249] Zinc Hyaluronate 10mg
[0250] Lactose 95mg
[0251] Microcrystalline cellulose (Avicel PH101) 95mg
[0252] The active ingredients and additives are made into pellets using known methods, such as in a vortex granulator. Pack the pellets in sachets, vials, or capsules. Example 4
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