Application of Trillium Tschnoskii Maxim in functional uterine bleeding

A uterine bleeding and functional technology, applied in the application field of medicine, can solve problems such as single efficacy, and achieve the effect of convenient administration

Inactive Publication Date: 2021-04-16
YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention intends to provide the application of a bead on the top of the head in functional uterine blee...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take a pearl medicinal material (dried rhizome) on the top of the head, pulverize it, and pass through a 100-mesh sieve to obtain a medicinal powder, take 5kg, fill capsules (0.5g per capsule), and obtain 9850 capsules. Three times a day, 1 capsule each time.

Embodiment 2

[0033] Take a bead on the top of the head medicinal material (dried rhizome), crush it, pass through a 10-mesh sieve, take 5 kg, add 4 times the volume percentage to 75% ethanol solution (a bead on the top of the head medicinal material: alcohol = 1kg: 4L) heat reflux extraction three times , filtered, combined three extracts, concentrated into extract (relative density needs to be controlled at 1.15-1.25, specifically 1.20 in this scheme), weighed 500g starch, and granulated with a volume percentage of 60% ethanol solution, 70 Dry at ℃, granulate, fill capsules (0.1g per capsule), and obtain 9880 capsules. Three times a day, 1 capsule each time.

experiment example 1

[0034] Experimental example 1: Study on the hemostatic effect of drugs

[0035] 1. Sample

[0036] Positive control group: Gongxuening Capsules (Yunnan Baiyao Group Co., Ltd., specification 0.13g / capsule, product batch number ZMA1402), prepared into 3.38mg / ml suspension with distilled water, daily dose 0.3ml;

[0037] Y-1 sample high-dose group: get the sample (medicine powder) prepared in Example 1 and add water to make 6.50mg / ml suspension, daily dose 0.3ml;

[0038] Y-1 sample low-dose group: get the sample (medicine powder) prepared in Example 1 and add water to make 3.25mg / ml suspension, daily dose 0.3ml;

[0039] Y-2 sample high-dose group: get the sample (extract) prepared in Example 2 and add water to make a 1.30mg / ml suspension, with a daily dose of 0.3ml;

[0040] Y-2 sample low-dose group: get the sample (extract) prepared in Example 2 and add water to make 0.650mg / ml suspension, daily dose 0.3ml;

[0041] Normal group: normal saline;

[0042] Control group 1: T...

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PUM

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Abstract

The invention relates to the technical field of new application of traditional Chinese medicine, in particular to application of Trillium Tschnoskii Maxim in preparing a medicine for treating functional uterine bleeding. The Trillium Tschnoskii Maxim is rich in pennogenyl saponin, has good hemostatic and uterine contraction effects, has small toxic and side effects, and can be used for treating clinical dysfunctional uterine bleeding. The medicine is simple and convenient in preparation process, small in dosage, small in toxic and side effects, low in price and economical, and has good development and application values.

Description

technical field [0001] The invention relates to the technical field of new uses of traditional Chinese medicine, in particular to the application of a bead on the top of the head in the preparation of medicine for treating functional uterine bleeding. Background technique [0002] Dysfunctional uterine bleeding, referred to as dysfunctional uterine bleeding or dysfunctional uterine bleeding, is a common gynecological disease. The main clinical manifestations are abnormal menstrual cycle frequency, regularity, menstrual length, and menstrual bleeding volume, often accompanied by anemia and infection. Dysfunctional uterine bleeding is caused by neuroendocrine disorders, not by systemic or organic diseases of the female genital tract such as pregnancy, endometrial tumors, infections, or blood disorders. At present, hemostasis is mainly treated clinically by taking hormone drugs such as compound gestodene, and surgical treatment such as curettage and hysterectomy is performed i...

Claims

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Application Information

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IPC IPC(8): A61K36/896A61K9/48A61P7/04A61P15/00A61P21/00A61K125/00
Inventor 刘录杨竹雅丁雄马晓霞王晓珍王钺涵谭文红周志宏
Owner YUNNAN UNIV OF TRADITIONAL CHINESE MEDICINE
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